Mental Disorder: Focus on Pathogenesis to Treatment
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 892
Special Issue Editor
Interests: complementary alternative medicine; neuroplasticity; non invasive brain stimulation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The etiology of mental disorders is multifactorial, involving a complex interplay of genetic, neurobiological, environmental, and psychological factors. Previous studies have identified numerous risk-conferring gene variants and polygenic risk scores associated with neurodevelopmental, neurotransmitter, and synaptic pathways. Neurobiological factors include dysregulations in neurotransmitter systems, structural/functional brain abnormalities, and neuroendocrine disturbances. Neuroimaging techniques have revealed alterations in regions like the prefrontal cortex, hippocampus, and amygdala. Prenatal insults, childhood adversity, stressful life events, and socioeconomic disadvantages increase vulnerability through mechanisms such as hypothalamic–pituitary–adrenal axis dysfunction, inflammation, and oxidative stress. Psychological factors like maladaptive coping strategies and personality traits modulate illness trajectories. Environmental exposures like toxins further exacerbate risk. Elucidating these complex pathways is crucial for developing personalized prevention, diagnostic, and therapeutic strategies tailored to individual risk profiles.
Dr. Carmen Concerto
Guest Editor
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Keywords
- mental disorders
- neurobiological
- oxidative stress
- neuroinflammation
- gene variants
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