Special Issue "Kawasaki Disease in Children and Adolescents"

A special issue of Children (ISSN 2227-9067).

Deadline for manuscript submissions: 1 December 2018

Special Issue Editor

Guest Editor
Prof. Dr. Robert Tulloh

Bristol Royal Hospital for Children, Bristol Heart Institute andUniversity of Bristol, UK
Website | E-Mail
Interests: congenital cardiology; pulmonary hypertension; Kawasaki disease; education; respiratory syncitial virus

Special Issue Information

Dear Colleagues,

Kawasaki disease was once a rare diagnosis, but now it is increasingly common. The recent British Paediatric Surveillance Unit study showed that there were 19% of children with coronary artery aneurysms as a consequence. It also showed that the incidence is increasing and globally, we find that the incidence is doubling every 10 years. These may have life-long effect on the developing child. Those most likely to develop such aneurysms live in rural areas, and have fewest of the associated clinical features, are diagnosed late and treated late as a consequence.

Sadly, many clinicians in the Western world believe that this condition is too rare to be seen on the wards. We hope that this Special Issue will highlight the areas of concern, those where there is lack of knowledge and those where there is more work to be undertaken, raising awareness as a consequence for the benefit of future children.

Prof. Dr. Robert Tulloh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Kawasaki Disease
  • Coronary artery aneurysm
  • Intravenous immunoglobulin
  • Infants
  • Adolescents
  • Coronary artery disease

Published Papers (1 paper)

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Review

Open AccessReview A Decade of NT-proBNP in Acute Kawasaki Disease, from Physiological Response to Clinical Relevance
Children 2018, 5(10), 141; https://doi.org/10.3390/children5100141
Received: 11 September 2018 / Revised: 5 October 2018 / Accepted: 8 October 2018 / Published: 12 October 2018
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Abstract
Kawasaki disease (KD) is an inflammatory febrile illness of early childhood and the primary cause of acquired heart disease during childhood. Coronary artery aneurysms (CAA) are a serious complication of KD, leading to ischemic heart disease, myocardial infarction, and sudden cardiac death. Timely
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Kawasaki disease (KD) is an inflammatory febrile illness of early childhood and the primary cause of acquired heart disease during childhood. Coronary artery aneurysms (CAA) are a serious complication of KD, leading to ischemic heart disease, myocardial infarction, and sudden cardiac death. Timely diagnosis in the first ten days of fever is crucial to reduce the risk of coronary artery complications. Nitrogen-terminal B-type natriuretic peptide (NT-proBNP), originally used for the management of adults with heart disease, was shown to be useful in the diagnosis and management of patients with KD. NT-proBNP is released by cardiomyocytes in response to mechanical factors such as the dilation of cardiac chambers, and to pro-inflammatory cytokines. The utility of NT-proBNP as a biological marker in KD is based on the universal myocardial inflammatory component early in the course of the disease. Patients with KD have higher NT-proBNP at the time of diagnosis than febrile controls, with a pooled sensitivity of 89% (95% confidence interval 78–95), and a specificity of 72% (95% confidence interval 58–82). The positive likelihood ratio is 3.2:1 (95% confidence interval 2.1–4.8). Moreover, patients with resistance to intravenous immunoglobulin treatment and CAA were found to have higher levels of NT-proBNP, suggesting a prognostic role. Nevertheless, the non-specificity of NT-proBNP to KD limits its use as a stand-alone test. In this light, a tentative associative retrospective diagnostic algorithm was highly reliable for including all cases at risk of CAA, which warrants further prospective studies for a better diagnostic index of suspicion and risk stratification of patients. Full article
(This article belongs to the Special Issue Kawasaki Disease in Children and Adolescents)
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