Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
3.8
2.1
Journals
Children
Special Issues
Acute and Chronic Lung Disease of the Neonate: Open Challenges...
share announcement

Acute and Chronic Lung Disease of the Neonate: Open Challenges and Novel Insights (Second Edition)

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Pulmonary and Sleep Medicine".

Deadline for manuscript submissions: closed (15 January 2026) | Viewed by 3390

Special Issue Editor

Dr. Maria Pierro

E-Mail Website
Guest Editor
Neonatal and Paediatric Intensive Care Unit, Maurizio Bufalini Hospital, AUSL Romagna, Cesena, Italy
Interests: bronchopulmonary dysplasia; neonates; lung ultrasound; mechanical ventilation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Respiratory disorders are the leading causes of admission to neonatal intensive care units, carrying high rates of mortality and morbidity. The definition and characterization of neonatal lung disorders are still a matter of debate. Preclinical and clinical research pertaining to novel ventilation strategies that may decrease the burden of superimposed ventilator-induced lung injury is a continuous field of improvement in neonatology. The point-of-care evaluation of the respiratory and cardiovascular system is constantly growing and constitutes a potential game-changer when dealing with neonatal lung diseases.

The purpose of this Special Issue is to collect contributions of clinical practice and research on neonatal lung diseases. This volume intends to provide novel insights into neonatal lung diseases, including prevention, diagnosis, monitoring, ventilator strategies and ECMO, novel treatments, supportive strategies and long-term outcomes. In addition to reviews, all types of research papers, from laboratory studies to pro- and retrospective clinical trials, are most welcome. Outstanding case reports with clear added scientific value are also acceptable.

Considering the popularity of the Special Issue "Acute and Chronic Lung Disease of the Neonate: Open Challenges and Novel Insights" previously published in Children (https://www.mdpi.com/journal/children/special_issues/8B3P4L6DAD), we now release a second Special Issue aiming to gather original research papers and review articles related to acute and chronic neonatal lung disease. We look forward to potentially collaborating with you and hope to hear back from you soon.

Dr. Maria Pierro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute lung disease of prematurity
  • neonatal acute respiratory distress syndrome
  • transient tachypnea of the newborn
  • chronic lung disease of prematurity
  • bronchopulmonary dysplasia
  • ventilator-induced lung injury

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Related Special Issue

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Other

12 pages, 489 KB  
Article
Tailoring Therapy to Bronchopulmonary Dysplasia Phenotype: A Ten-Year Experience in Precision Medicine
by Arvind Sehgal and Samuel Menahem
Children 2026, 13(2), 275; https://doi.org/10.3390/children13020275 - 17 Feb 2026
Viewed by 782
Abstract
Aims: To assess the impact of systemic afterload reduction on cardiorespiratory health in infants with a severe bronchopulmonary dysplasia (BPD)–systemic hypertension–left heart dysfunction (LHD) phenotype. Methods: Ten-year data were prospectively collected and analysed. The cohort included extremely preterm infants with severe BPD–systemic hypertension–LHD [...] Read more.
Aims: To assess the impact of systemic afterload reduction on cardiorespiratory health in infants with a severe bronchopulmonary dysplasia (BPD)–systemic hypertension–left heart dysfunction (LHD) phenotype. Methods: Ten-year data were prospectively collected and analysed. The cohort included extremely preterm infants with severe BPD–systemic hypertension–LHD pathophysiology, treated with systemic afterload reduction with captopril. Main outcome measures included improvement in oxygenation and echocardiographic measures of LHD. Results: Twenty-six infants with gestation of 26.5 ± 2 weeks and median (interquartile range) birthweight of 900 (582, 1083) g were administered captopril at the corrected gestation median (range) of 40 weeks (37–67). On reassessment after five weeks, oxygen requirements (43 ± 16% to 26 ± 7%, p = 0.0001) and paired pCO2 decreased (64 ± 9 to 53 ± 9 mm Hg, p = 0.0001). Significant improvements were seen in cardiac indices (diastolic: trans-mitral E/A ratio [1 ± 0.07 to 0.94 ± 0.07, p = 0.0004] and iso-volumic relaxation time [ms] [65 ± 3 to 56 ± 4, p < 0.0001], and systolic: mean velocity of circumferential fibre shortening [circ/s] [1.6 ± 0.2 to 1.9 ± 0.2, p < 0.0001] and left ventricular output [mL/kg/min] [177 ± 34 to 230 ± 54, p = 0.0002]). This coincided with improved aortic pulsatility (40 ± 13 to 50 ± 11 µm, p = 0.005). Conclusions: Systemic hypertension–LHD pathology amongst infants with severe BPD may be under-recognised. Systemic afterload reduction is physiologically suited in a subset of infants with severe BPD. Full article
(This article belongs to the Special Issue Acute and Chronic Lung Disease of the Neonate: Open Challenges and Novel Insights (Second Edition))
►▼ Show Figures

Figure 1

Other

Jump to: Research

17 pages, 2713 KB  
Systematic Review
Steroid Use for Established Bronchopulmonary Dysplasia: A Systematic Review and Meta-Analysis
by Maria Pierro, Roberto Chioma, Krzysztof Włodarczyk, Margit Benke, Kaushik Mangroo, Maria Chiara Vetrano, Kinga Zielińska, David O’Keeffe, Joanna Seliga-Siwecka, Helen Purtill, Niazy Al-Assaf, Eduardo Villamor and Roy K. Philip
Children 2025, 12(9), 1238; https://doi.org/10.3390/children12091238 - 16 Sep 2025
Cited by 1 | Viewed by 2278
Abstract
Introduction: Evidence on steroid treatment for established bronchopulmonary dysplasia (BPD) is sparse. To our knowledge, a systematic review has never been conducted on this topic. This meta-analysis aims to synthesize available evidence for the use of postnatal steroids to treat established BPD. Methods: [...] Read more.
Introduction: Evidence on steroid treatment for established bronchopulmonary dysplasia (BPD) is sparse. To our knowledge, a systematic review has never been conducted on this topic. This meta-analysis aims to synthesize available evidence for the use of postnatal steroids to treat established BPD. Methods: MEDLINE, Embase, Cochrane databases, and gray literature sources were searched without time or language restrictions until October 2024. We included randomized and non-randomized trials (analyzed separately) that evaluated postnatal steroids started from 28 days of life in preterm infants diagnosed with BPD. Certainty of evidence was assessed using the GRADE approach. Results: The search retrieved 9113 records, and 20 studies were included. Meta-analysis of the RCTs demonstrated that steroids significantly reduced oxygen requirement (daily mean difference of 1.6%, 95% CI 0.25–2.95), but the analysis did not identify significant differences in total duration of supplemental oxygen, length of stay, or mortality (moderate quality). From a safety perspective, steroids resulted in a transient increase in systemic blood pressure (mean difference of 6.8 mmHg, 95% CI 4.6–8.9) (moderate quality). Weight gain during treatment was lower in the systemic steroid group (−9.2 g/day, 95% CI −11.7 to −6.8) (moderate quality), although overall growth was reported as equal (2.4 g/day, 95% CI −0.3 to 6.3) (moderate quality). One retrospective study reported the incidence of steroid treatment among infants with established BPD (any definition) to be as high as 36%. Two single-arm studies reported a prolonged high-dose systemic steroid regimen as the routine treatment strategy for severe established BPD. Conclusions: Moderate quality of evidence suggests that steroid treatment cannot be recommended as standard of care for established BPD. However, corticosteroids are often used to this end. Large-scale RCTs designed to treat BPD are urgently needed. Furthermore, careful consideration for patient selection and compliance with GRADE methodology is essential. Full article
(This article belongs to the Special Issue Acute and Chronic Lung Disease of the Neonate: Open Challenges and Novel Insights (Second Edition))
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop