Pediatric Kidney Disease: Prevalence, Risk, and Management Strategies

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Nephrology & Urology".

Deadline for manuscript submissions: 25 May 2026 | Viewed by 776

Special Issue Editor


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Guest Editor
1. Department of Pediatric Nephrology, Cluj-Napoca Children’s Hospital Gheorghieni, 400023 Cluj-Napoca, Romania
2. Faculty of Nursing and Health Sciences, Department 2, University of Medicine and Pharmacy “Iuliu Hatieganu”, 400023 Cluj-Napoca, Romania
Interests: pediatric ultrasound; pediatric nephrology
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Special Issue Information

Dear Colleagues,

Pediatric kidney disease is an increasingly recognized health challenge, with significant implications for growth, development, and long-term well-being. Understanding its prevalence, associated risk factors, and optimal management strategies is critical in improving outcomes in affected children. Over the decades, research has advanced from basic epidemiological studies to sophisticated insights into genetic predispositions, environmental influences, and innovative therapeutic interventions.

This Special Issue will highlight cutting-edge research that enhances our understanding of pediatric nephrology, encompassing early detection, risk stratification, and evidence-based management approaches.

We invite high-quality contributions comprising original research, reviews, and clinical studies that address novel mechanisms, preventive strategies, and practical interventions. By consolidating these insights, this Special Issue will guide clinicians and researchers in optimizing care for children with kidney disease.

Dr. Andreea Liana Bot (Rachisan)
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • kidney
  • risk factors
  • epidemiology
  • management
  • transplantation

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Published Papers (1 paper)

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Review

11 pages, 658 KB  
Review
ATP6V1B1-Associated Inherited Distal Renal Tubular Acidosis in Children: Insights from a Literature Review
by Andreea Liana Bot (Rachisan), Marius Cosmin Colceriu, Diana Jecan-Toader, Bogdan Bulata, Dan Delean and Mihaela Sparchez
Children 2026, 13(3), 436; https://doi.org/10.3390/children13030436 - 23 Mar 2026
Viewed by 507
Abstract
Inherited distal renal tubular acidosis (dRTA) is a rare but clinically significant disorder of renal acid–base regulation that frequently presents in infancy or early childhood. Among the genetic causes of autosomal recessive dRTA, mutations in the ATP6V1B1 gene are particularly important due to [...] Read more.
Inherited distal renal tubular acidosis (dRTA) is a rare but clinically significant disorder of renal acid–base regulation that frequently presents in infancy or early childhood. Among the genetic causes of autosomal recessive dRTA, mutations in the ATP6V1B1 gene are particularly important due to their association with early-onset disease and sensorineural hearing loss. Failure to recognize and treat this condition promptly can result in growth retardation, bone disease, nephrocalcinosis, chronic kidney disease, and permanent auditory impairment. This article presents a comprehensive review of the pediatric literature concerning dRTA. We focus on the pathophysiology, pediatric presentation, renal and audiological outcomes, genetic architecture, and management implications of ATP6V1B1-associated dRTA in children. We highlight evolving genotype–phenotype correlations, the emerging recognition of autosomal recessive disease mechanisms, and the importance of early diagnosis and long-term multidisciplinary follow-up. Full article
(This article belongs to the Special Issue Pediatric Kidney Disease: Prevalence, Risk, and Management Strategies)
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