Special Issue "Pediatric Acute Myeloid Leukemia: Current Management and Future Directions"
Deadline for manuscript submissions: closed (31 December 2019).
Interests: pediatric AML; chemotherapy resistance; microenvironment; signal transduction; novel agents; mouse models
While tremendous advances have been made in improving outcomes for children with cancer in general, progress for children with acute myeloid leukemia (AML) has been relatively slow. Chemotherapy intensity has been pushed to the limit of tolerability, and still, nearly 40% of children will suffer relapse. As we expand our understanding of the biology of the disease, we expect that new approaches to risk stratification, therapy, and supportive care will emerge. This Special Issue of Children will bring together the most current basic, translational, and clinical research focused on this challenging disease. Both reviews and original research will be considered for publication. Basic and translational research topics could include genomic/transcriptomic/proteomic studies, small molecule therapies, immunotherapies, and biology studies with clinical samples. Clinical research topics could include new approaches to upfront treatment, minimal residual disease detection, stem cell transplantation, salvage therapy, and management of AML in resource-poor settings.
Dr. Michele S. Redell
Dr. Alexandra M. Stevens
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- acute myeloid leukemia
- structural rearrangement
- risk stratification
- epigenetic mechanisms of leukemogenesis
- chemotherapy resistance
- kinase inhibitors
- stem cell transplant
- opportunistic infections
- supportive care