Mental Health and Well-Being of Children with Gender Variability

A Special Issue of Children (ISSN 2227-9067) belonging to the section "Pediatric Mental Health".

Deadline for manuscript submissions: closed (15 September 2026) | Viewed by 1430

Editors


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Faculty of Health Sciences and Nursing, Universidade Católica Portuguesa, 1649-023 Lisbon, Portugal
Interests: nursing care; childcare; hope; clinical practice; literature review; appreciative inquiry; mutual help groups; chronic disease
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Guest Editor
Faculty of Nursing and Cumming School of Medicine (Pediatrics, Psychiatry & Community Health Sciences), University of Calgary, Calgary, AB T2N 1N4, Canada
Interests: parent–infant/child relationships; perinatal mental health; infant mental health; vulnerable children; parent–child interventions; social support; domestic abuse; toxic stress; adverse childhood experiences; child development and health; biological sensitivity; genetics; epigenetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The mental health and well-being of children and adolescents with gender variability are critical areas of research, given the growing number of referrals to specialist gender services.

Gender variance during childhood can significantly impact self-concept and lead to mental health challenges, including increased risks of suicidal ideation in later life.

This Special Issue aims to explore the mental health disparities, the effects of gender discrimination, and the intersection of gender diversity with other conditions, such as autism spectrum disorder and bullying.

We invite researchers to contribute innovative studies and evidence-based approaches that enhance understanding and improve care for gender-diverse youth.

[*] Background & history of this topic:

The topic of gender identity and mental health in children and adolescents has gained increasing attention. The existence of trans and non-binary children has been recognized since the early twentieth century, although their experiences and rights have been largely ignored or marginalized. These children were often labelled as "confused," pathologized, and subjected to medical treatments to suppress their gender nonconformity, reflecting social discomfort with non-binary gender expressions.

When parents, family, schools, and society observe this situation, they often respond swiftly. They assure the child or young person that it is merely a phase, implying that their desires and motivations are not crucial for their development. Although global guidelines advocate for involving children and young people in decision-making, the approach to this varies worldwide. Furthermore, gender discrimination, including maternal exposure to bias, has been linked to increased emotional and behavioral challenges in children.

Children and teens who do not identify with their birth gender often have more emotional and behavioral problems than those who do. Being different in gender during childhood can hurt self-esteem and cause mental health issues like anxiety, depression, and thoughts of suicide. These problems can continue into adulthood.

The invisibility and disability attributed to trans and nonbinary children are reinforced by legal and social systems that often ignore their voices and needs.

[*] Aim and scope of the Special Issue:

This Special Issue aims to address the mental health challenges faced by gender-diverse youth and explore strategies to mitigate these effects. It seeks to highlight the importance of integrated services that address the spectrum of gender variance and the need for gender-sensitive mental health care in the region. This Special Issue also aims to provide a platform for discussing the social determinants of health and their effects on gender-diverse youth, as well as the integration of sexual health services and mental health care.

[*] Cutting-edge research:

Various aspects of gender identity and mental health in children and adolescents may be included in this Special Issue:

- Disparities and Risks: analysis of protective factors against suicidal ideation and anxiety.
- Social Determinants: the impact of exposure to discrimination on the family and school nucleus.
- Neurodivergence: understand the overrepresentation of ASD in gender-diverse youth.
- Gender Differences: research on specific vulnerability in children and adolescents.

[*] What kind of papers we are soliciting:

We invite researchers to submit original articles, systematic reviews, case studies, and theoretical analyses that explore the following themes:

  • Intersectionality and mental health of gender-diverse children.
  • Impact of gender discrimination on children's mental health.
  • Strategies to promote well-being and resilience in children and adolescents with gender variability.
  • Integration of mental and sexual health services for gender-diverse youth.
  • Studies on the relationship between gender variability and autism spectrum disorders.

Dr. Zaida Charepe
Prof. Dr. Nicole L. Letourneau
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mental health
  • well-being
  • gender identity
  • children
  • adolescent
  • hope
  • resilience
  • parental role
  • inclusion
  • transition

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Published Papers (1 paper)

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Research

18 pages, 587 KB  
Article
Retrospective Cohort Study of Transgender Adolescents at Strasbourg University Hospital
by Camille Schunder, Agnès Gras-Vincendon and François Brezin
Children 2026, 13(6), 789; https://doi.org/10.3390/children13060789 - 6 Jun 2026
Viewed by 915
Abstract
Introduction: Medical care for transgender minors is understudied, largely because these forms of care are relatively recent. The primary objective of this work was to describe the cohort of transgender adolescents who initiated follow-up at the Strasbourg University Hospital before the age of [...] Read more.
Introduction: Medical care for transgender minors is understudied, largely because these forms of care are relatively recent. The primary objective of this work was to describe the cohort of transgender adolescents who initiated follow-up at the Strasbourg University Hospital before the age of 18, whether or not they began hormone therapy prior to reaching adulthood. Method: This was an observational, retrospective, single-center, descriptive study conducted among adolescents who had attended at least one consultation in our center before the age of 18 between January 2017 and March 2024. Results: Our population consisted of 115 patients predominantly made up of transmasculine (AFAB) adolescents (68%). Compared with the general population, we observed significantly higher rates of psychiatric co-occurrences, autism spectrum disorder (ASD), and attention-deficit/hyperactivity disorder (ADHD). Only 46.1% initiated gender-affirming hormone therapy (GAHT) in our cohort, and just 34.8% before age 18. A total of 6% of adolescents received puberty blockers as monotherapy. The mean age at GAHT initiation was 16.99 years. Transition pathways appear to differ according to the adolescent’s type of schooling. The rate of retransition/treatment interruption in our sample ranged from 0% to 6.1%, depending on the criteria applied. We did not identify any adolescent who retransitioned to their sex assigned at birth after starting GAHT by the end of the data collection. Discussion: The high prevalence of psychiatric co-occurrences raises important questions regarding how to improve care for these adolescents. The predominance of AFAB adolescents similarly prompts reflection on the barriers that transfeminine adolescents may face when seeking to transition before adulthood. In addition, the substantial number of adolescents presenting with ASD or ADHD underscores the need for particular vigilance regarding their specific needs and overall well-being. Finally, the variability in retransition rates depending on the criteria applied highlights the absence of a consensual definition, which limits the comparability and validity of existing studies. Conclusions: Long-term prospective studies are needed to objectively demonstrate the effectiveness of current transition pathways. Academic research in this field should be strengthened, along with the development of larger prospective datasets, to improve the overall health of this population. Full article
(This article belongs to the Special Issue Mental Health and Well-Being of Children with Gender Variability)
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