|The inaugural issue was released. Challenges was published as a quarterly journal.
|Challenges adopted a biannual publication schedule.
|Challenges announced the first edition of the Best Research Proposal Prize.
|Challenges became an affiliated journal of the inVIVO Planetary Health.
|Challenges established the following sections:
|Challenges became an affiliated journal of the Nova Network (when inVIVO Planetary Health partnered with the Nova Institute for Health to create this new network).
|Editor-in-Chief: Prof. Dr. Andreas Manz
|Editor-in-Chief: Dr. Palmiro Poltronieri
|Editor-in-Chief: Prof. Dr. Susan L. Prescott