Journal History
| 2010 | The inaugural issue was released. Challenges was published as a quarterly journal. |
| 2012 | Challenges adopted a biannual publication schedule. |
| 2013 | Challenges announced the first edition of the Best Research Proposal Prize. |
| 2018 | Challenges became an affiliated journal of the inVIVO Planetary Health. |
| 2020 | Challenges established the following sections: -Trends; -Planetary Health; -Renewable Energies. |
| 2022 | Challenges became an affiliated journal of the Nova Network (when inVIVO Planetary Health partnered with the Nova Institute for Health to create this new network). |
| 2024 | Challenges established the following sections: -Human Health and Well-Being; -Regenerative Economies. |
Editor-in-Chief
| 2010–2015 | Editor-in-Chief: Prof. Dr. Andreas Manz |
| 2015–2019 | Editor-in-Chief: Dr. Palmiro Poltronieri |
| 2020–present | Editor-in-Chief: Prof. Dr. Susan L. Prescott |
