Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cancer and Vessels: Insights at the Cellular and Molecular Levels
edited by Francesco Pezzella and Tom Donnem
submission deadline 31 May 2026 | Viewed by 13 | Submission Open
Keywords: angiogenesis; vessel co-option; tumor microenvironment; tumor blood vessels; tumor vasculature; metastasis
(This special issue belongs to the Section Cellular Pathology)
Modeling Lung Regeneration and Injury Responses Using Organoids and Engineered Niches
edited by Tristan Frum
submission deadline 31 May 2026 | Submission Open
Keywords: lung biology; regeneration; stem cells; intra- and extracellular signaling; cell techniques; organoids; bioengineering
(This special issue belongs to the Section Tissues and Organs)
Molecular Bases Underlying Early Embryonic Development in Mammals
edited by , Julio Ávila Marrero and Angela Palumbo
submission deadline 31 May 2026 | Submission Open
Keywords: embryonic development; early embryogenesis; gene expression; miRNA profile; reproductive physiology; cell signalling; embryo quality; developmental competence; in vitro embryo culture
(This special issue belongs to the Section Reproductive Cells and Development)
Molecular Mechanisms of Fibrosis in Chronic Liver Diseases
edited by , Regina Golan-Gerstl and Ihab Ansari
submission deadline 1 Jun 2026 | Viewed by 186 | Submission Open
Keywords: liver fibrosis; MASH; immune checkpoints; epigenetic regulation; hepatic stellate cells (HSCs); antifibrotic therapy; molecular mechanisms; inflammation; ROS
Human Pluripotent Stem Cells and Organoids: Current Trends and Future Perspectives submission deadline 1 Jun 2026 | Viewed by 100 | Submission Open
Keywords: human pluripotent stem cells; organoids; disease modeling; regenerative medicine; genome editing; single-cell omics; tissue engineering; drug discovery; precision medicine
(This special issue belongs to the Section Stem Cells)
Macrophages in Cancer: Immunosuppression, Immunoregulation, and Immunotherapy
edited by
submission deadline 5 Jun 2026 | 2 articles | Viewed by 10060 | Submission Open
Keywords: macrophage; immunosuppression; immunoregulation; immunotherapy; tumor immune microenvironment
(This special issue belongs to the Section Cellular Immunology)
Novel Insights into Molecular Mechanisms and Therapy of Myeloma
edited by and
submission deadline 10 Jun 2026 | 6 articles | Viewed by 14955 | Submission Open
Keywords: multiple myeloma; CAR-T therapy; relapse; methylation; drug resistance; treatment strategy; molecular mechanism; novel target; biomarker
(This special issue belongs to the Section Cellular Pathology)
The Metabolic Edge: How Cancer Cells Adapt, Survive, and Resist Therapy
edited by
submission deadline 10 Jun 2026 | Viewed by 74 | Submission Open
Keywords: cancer metabolism; metabolic rewiring; therapy resistance; metabolic plasticity; nutrient uptake; mitochondrial remodeling; tumor microenvironment; metabolic vulnerabilities
(This special issue belongs to the Section Cellular Metabolism)
Lipid Mediators in Cardiometabolic Regulation and Disease
edited by Adeniyi Michael Adebesin
submission deadline 10 Jun 2026 | Viewed by 14 | Submission Open
Keywords: lipid mediators; lipoprotein; fatty acid metabolites; cellular membranes; cardiometabolic regulation; cellular metabolism; adipogenesis; signaling pathways; receptors; lipid transport proteins
(This special issue belongs to the Section Cellular Metabolism)
Molecular Mechanisms of Cardiac Repair and Regeneration
edited by Mahesh Thirunavukkarasu
submission deadline 10 Jun 2026 | Submission Open
Keywords: cardiac repair and regeneration; cardiomyocyte; cardiac fibrosis; signaling pathways; immune regulation; extracellular vesicles; stem cell therapies; epigenetics; biomarkers
(This special issue belongs to the Section Cells of the Cardiovascular System)
The Role of Oxidative Stress in Cardiovascular Diseases—2nd Edition
edited by and
submission deadline 15 Jun 2026 | 1 articles | Viewed by 3591 | Submission Open
Keywords: oxidative stress; antioxidants; apoptosis; atherosclerosis; blood vessel; heart failure; hypertension; inflammation; mitochondria; microcirculation; reactive oxygen species
(This special issue belongs to the Section Cells of the Cardiovascular System)
Novel Insights into Developing Therapeutic Strategies for Neurological Disorders
edited by , Joanna A. Korecka and
submission deadline 15 Jun 2026 | Viewed by 202 | Submission Open
Keywords: neurological disorders; RNA therapeutics; gene therapy; antisense oligonucleotides; gene editing; cell therapy; precision medicine; neurodegenerative diseases; neurodevelopmental disorders; neurogenetic disorders
Regulation of Hormone Secretion from Islets in Health and Disease
edited by
submission deadline 15 Jun 2026 | Viewed by 199 | Submission Open
Keywords: islet hormone secretion; paracrine signaling; autocrine regulation; intra-islet communication; islet cell plasticity; transdifferentiation; multi-hormonal dysregulation; circadian regulation; single-cell omics; islet inflammation and immune crosstalk
Genomics and Cellular Mechanisms in Ovarian Cancer
edited by Hao Huang
submission deadline 15 Jun 2026 | Viewed by 139 | Submission Open
Keywords: ovarian cancer; tumor heterogeneity; genomics and epigenomics; therapy resistance; tumor microenvironment
(This special issue belongs to the Section Tissues and Organs)
Overcoming Resistance to Immune Checkpoint Inhibitors in Cancer: Mechanisms, Models, and Therapeutic Strategies
edited by Nai-Yun Sun, and
submission deadline 15 Jun 2026 | Viewed by 71 | Submission Open
Keywords: immune checkpoint inhibitors; primary resistance; acquired resistance; tumor microenvironment; immune exhaustion; preclinical cancer models; genetic and epigenetic alterations; excluded/desert tumors; inflamed tumors; cancer immunotherapy
Bone and Soft Tissue Tumors: Molecular Mechanisms and Emerging Therapeutics
edited by
submission deadline 15 Jun 2026 | Viewed by 57 | Submission Open
Keywords: sarcoma; bone and soft tissue tumors; molecular pathology; dysregulated signaling pathways; genetic and epigenetic alterations; therapeutic resistance; novel molecular biomarkers; therapeutic strategies; in vitro and in vivo models
Mechanisms of Antimicrobial Treatment in Human Diseases
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 2900 | Submission Open
Keywords: multidrug resistance; epidemiology; novel antimicrobial resistance traits
(This special issue belongs to the Section Cellular Pathology)
Decoding the Complexity of Angiogenesis: Insights into Vascular Formation and Disease submission deadline 20 Jun 2026 | 3 articles | Viewed by 2319 | Submission Open
Keywords: angiogenesis; vasculogenesis; development; physiological angiogenesis; pathophysiology; cell– cell communication; cell signaling
(This special issue belongs to the Section Cells of the Cardiovascular System)
Biomolecular Condensates in Oncology and Immunology submission deadline 20 Jun 2026 | 1 articles | Viewed by 1552 | Submission Open
Keywords: liquid-liquid phase separation (LLPS); biomolecular condensates; pro-oncogenic signaling; innate and adaptive immunity; transcriptional regulation; epigenetic regulation; condensate targeting; antiviral mechanisms; intercellular adhesion; cell migration and metastasis
(This special issue belongs to the Section Cellular Immunology)
Progress of Nanoparticles in the Treatment of Cancers
edited by and Nafees Ahamad
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1352 | Submission Open
Keywords: nanoparticles; cancer treatment; cellular mechanisms; molecular biology; pathophysiology; drug delivery; drug resistance; immunotherapy; tumor microenvironment
(This special issue belongs to the Section Cell Microenvironment)
Beyond Bystanders: The Emerging Roles of Glia in Brain Health and Disease
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 843 | Submission Open
Keywords: astrocytes; microglia; oligodendrocytes; neuroinflammation; neuroimmunology; synaptic plasticity; blood– brain barrier; neuropsychiatric disorders
(This special issue belongs to the Section Cellular Neuroscience)
Molecular Anatomy and Function of Sensory Organs and Sensory Tissues
edited by
submission deadline 20 Jun 2026 | Viewed by 297 | Submission Open
Keywords: sensory organ; sensory tissue; vision; hearing; skin; sensory structures of internal organs
(This special issue belongs to the Section Tissues and Organs)
New Insights into Astrocytes in Health and Disease
edited by
submission deadline 20 Jun 2026 | Viewed by 127 | Submission Open
Keywords: astrocytes heterogeneity; blood-brain barrier (BBB); synaptic modulation; metabolic support; neuroinflammation; ageing; neurodegenerative disorders; neurodevelopmental disorders; stress response
(This special issue belongs to the Section Cellular Neuroscience)
The Orchestration of Glial Cells in Health and Disease
edited by Keying Zhu
submission deadline 25 Jun 2026 | 1 articles | Viewed by 1194 | Submission Open
Keywords: microglia; oligodendrocytes; astrocytes; myelin; neuroinflammation
Extracellular Vesicles Based Drug Delivery submission deadline 25 Jun 2026 | Viewed by 400 | Submission Open
Keywords: EV engineering; targeting; therapy; natural carrier; exosomes
Regenerating Poorly Vascularized Tissues
edited by Simone Pacini
submission deadline 25 Jun 2026 | Viewed by 245 | Submission Open
Keywords: regenerative medicine; avascular tissue; angiogenesis; vasculogenesis; cell-based medicinal products; bioengineered materials; cell transplantation
(This special issue belongs to the Section Tissues and Organs)
Novel Insights in Chronic Epilepsy—from Molecular Mechanisms to Future Therapies
edited by Kjell Heuser and
submission deadline 25 Jun 2026 | Viewed by 31 | Submission Open
Keywords: epilepsy; epileptogenesis; seizure mechanisms; neuroinflammation; glial cells; reactive gliosis; astrocytes; microglia; antiseizure medication
Cutaneous Regeneration and Tissue Engineering: From Hair Follicle Regeneration to Skin Restoration
edited by Soung-Hoon Lee
submission deadline 25 Jun 2026 | Viewed by 29 | Submission Open
Keywords: skin regeneration; hair follicle regeneration; tissue engineering; regenerative biology; biomaterial scaffolds; organoids and 3D skin models; wound healing; acellular matrices; exosome-based therapy; translational dermatology
The Function of Stem Cells in the Biomedical Applications
edited by Rakesh Kumar Srivastava
submission deadline 25 Jun 2026 | Viewed by 27 | Submission Open
Keywords: stem cells; regenerative medicine; cell therapy; differentiation; disease modeling; tissue engineering; drug discovery
Inflammation and Atherosclerosis: Emerging Mechanisms, Biomarkers and Therapeutic Opportunities
edited by Victoria McGilligan
submission deadline 25 Jun 2026 | Viewed by 24 | Submission Open
Keywords: atherosclerosis; inflammation; inflammatory biomarkers; anti-inflammatory therapies; plaque vulnerability; diagnostics and prognostics
Systemic Sclerosis: Cellular Mechanisms, Innovative Diagnostics and Advanced Therapeutics
edited by Muhammad Soyfoo
submission deadline 25 Jun 2026 | Viewed by 20 | Submission Open
Keywords: systemic sclerosis; fibrosis; myofibroblasts; immune dysregulation; endothelial dysfunction; extracellular matrix (ECM); autoimmune disease
Diabetes-Induced Organ Damage: Cellular Mechanisms and Therapeutic Opportunities submission deadline 30 Jun 2026 | 8 articles | Viewed by 33494 | Submission Open
Keywords: diabetes mellitus; vascular lesions; nephropathy; cardiomyopathy; neuropathy; retinopathy; therapeutic opportunities
(This special issue belongs to the Section Tissues and Organs)
Exclusive Review Papers in Parkinson's Research
edited by and Ronald F. Pfeiffer
submission deadline 30 Jun 2026 | 1 articles | Viewed by 8179 | Submission Open
Keywords: Parkinson’ s disease; alpha-synuclein; substantia nigra; mitochondria; non-motor symptoms; dopamine; levodopa
(This special issue belongs to the Section Cellular Aging)
Pathology and Treatments of Amyotrophic Lateral Sclerosis (ALS)
edited by Laxman Gangwani
submission deadline 30 Jun 2026 | 2 articles | Viewed by 4467 | Submission Open
Keywords: amyotrophic lateral sclerosis (ALS); pathology; molecular mechanisms; treatments; symptom management; biological mechanisms; risk factors; innovative treatments
(This special issue belongs to the Section Cellular Pathology)
Emerging Topics in Smooth Muscle Cell Fate and Plasticity in Atherosclerosis submission deadline 30 Jun 2026 | 3 articles | Viewed by 3612 | Submission Open
Keywords: vascular smooth muscle cells; lineage tracing; fate mapping; VSMC plasticity; (single cell) (spatial) omics; vascular heterogeneity; atherosclerosis
(This special issue belongs to the Section Cellular Pathology)
Study on Immune Activity of Natural Products
edited by Xiu-Min Li
submission deadline 30 Jun 2026 | 3 articles | Viewed by 2430 | Submission Open
Keywords: natural products; bioactive compounds; immune activity; immunomodulation; inflammation; autoimmune diseases; immunotherapy; therapeutic potential
MicroRNAs: Regulators of Cellular Fate
edited by
submission deadline 30 Jun 2026 | 2 articles | Viewed by 1847 | Submission Open
Keywords: microRNA targets; microRNA conservation; microRNA pathway; microRNA mimics; microRNA antagonist; disease biomarker
Emerging Topics in Cachexia
edited by Gabriela Salim Ferreira De Castro
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1102 | Submission Open
Keywords: cachexia; skeletal muscle loss; adipose tissue loss; inflammation; sarcopenia; cancer; body composition; biomarkers
Cellular and Molecular Mechanisms in Gastrointestinal Diseases submission deadline 30 Jun 2026 | Viewed by 484 | Submission Open
Keywords: gastrointestinal pathophysiology  ; epithelial– mesenchymal transition (EMT)  ; inflammation and immune regulation  ; tumor microenvironment  ; cell signaling pathways  ; stem cell biology in GI tract  ; molecular biomarkers  ; organoids and disease modeling  ; microbiome– host interactions  ; drug discovery
(This special issue belongs to the Section Tissues and Organs)
Retinoic Acid and Retinoid X Receptors - Series II submission deadline 30 Jun 2026 | Viewed by 468 | Submission Open
Keywords: nuclear receptor signaling; retinoic acid receptor; retinoid X receptor; pharmacology; structure/function relationships; genomic and non-genomic signaling; post-translational modification; homeostasis and disease; development; origin and evolution
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Kidney and Lung Disorders: The Role of Tubular and Alveolar Epithelia in Health, Disease, Infection, and Organ Crosstalk
edited by Aparna Renigunta and
submission deadline 30 Jun 2026 | Viewed by 306 | Submission Open
Keywords: renal tubular disorders; alveolar lung diseases; transport mechanism; intracellular signaling; viral infection; crosstalk; dialysis; ventilation
Nuclear Pore Complex in Nanomedicine: Third Edition
edited by
submission deadline 30 Jun 2026 | Viewed by 258 | Submission Open
Keywords: intracellular transport; NPC; mitosis; nano; cancer; brain
Protein and RNA Regulation in Cells
edited by and
submission deadline 30 Jun 2026 | Viewed by 201 | Submission Open
Keywords: gene expression; post-transcriptional regulation; post-translational modifications; non-coding RNAs; regulatory networks; protein degradation; RNA decay
Crossroad Between Oxidative Stress and DNA Damage and Repair in Stroke
edited by , and Moorthi Ponnusamy
submission deadline 30 Jun 2026 | Viewed by 197 | Submission Open
Keywords: oxidative stress; DNA damage; DNA repair; stroke; ischemic stroke; neuroinflamamtion; intracranial hemorrhagic stroke; neuronal death
(This special issue belongs to the Section Cellular Neuroscience)
The Role of PPARs in Disease - Volume IV submission deadline 30 Jun 2026 | Viewed by 134 | Submission Open
Keywords: PPAR; immune function; liver; adipose tissue; cardiovascular system; muscle; brain; neurological disease; psychiatric diseases; cancer; transcriptional regulation; ligands; agonists/antagonists
(This special issue belongs to the Section Cells of the Cardiovascular System)
Cellular and Molecular Mechanisms of Hepatobiliary Diseases submission deadline 30 Jun 2026 | Viewed by 126 | Submission Open
Keywords: hepatobiliary diseases; bile metabolism; hepatobiliary models; artificial intelligence; cholestatic diseases; systems medicine; spatio-temporal liver models
(This special issue belongs to the Section Tissues and Organs)
Cellular and Molecular Mechanisms in Reproductive Biology and Fertility
edited by and Antonio Malvasi
submission deadline 30 Jun 2026 | Viewed by 99 | Submission Open
Keywords: gametogenesis; fertilization; fertility; endocrinology; implantation; gametogenesis regulation; embryo– maternal interaction; reproductive signaling; IVF; in vitro fertilization; ovarian stimulation
(This special issue belongs to the Section Reproductive Cells and Development)
Bone and Tooth Biology: Development and Regeneration
edited by Xiaofang Wang
submission deadline 30 Jun 2026 | Viewed by 88 | Submission Open
Keywords: bone; tooth; osteogenesis; odontogenesis; enamel; dentin; cementum; amelogenesis; dentinogenesis; regeneration; stem cells  
Mitochondrial Dynamics and Remodelling
edited by Edmund Carvalho
submission deadline 30 Jun 2026 | Viewed by 84 | Submission Open
Keywords: mitochondrial dynamics; fission; fusion; mitophagy; cristae remodeling; bioenergetics; ER– mitochondria contacts; immune reprogramming; signaling pathways; therapeutic targeting
Tau Pathobiology and Excitotoxicity in Neurodegeneration and Epilepsy
edited by Janet Van Eersel
submission deadline 30 Jun 2026 | Viewed by 62 | Submission Open
Keywords: tau; excitotoxicity; dementia; epilepsy; seizures; hyperexcitation
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