Special Issue "Regulation of Erythropoiesis—Building a Red Blood Cell"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (30 November 2020).
Interests: transcriptional regulation of erythropoiesis; Kruppel-like factor 1 (KLF1) and networks; congenital anemias; JAK–STAT signalling in stress erythropoieis and myeloproliferative neoplasms
In healthy humans, erythropoiesis ensures the production of more than two million red blood cells (RBCs) every second. This can be increased 5–10-fold in response to increased requirements. There is a rich history of productive global collaborations between researchers and haematologists with diverse skill sets, which has led to our current comprehensive understanding of the ontogeny, cell biology, genetics, and genomics of erythropoiesis. Many pioneering discoveries in the field have led the way to a greater understanding of cell differentiation processes in general. RBCs are exquisitely built for one purpose, i.e., the transport of oxygen from the lungs to every cell in the body. This review series will track the journey of red blood cell (RBC) production in time and place, and from genetic blueprint to final construction. The series will integrate new knowledge about ontogeny, the niche, transcription, RNA processing and translation, cytokine signalling and stress responses, cell cycle control, and enucleation. We will attempt to integrate our understanding of the normal physiology and genetics of erythropoiesis with the aberrant differentiation that ensues from inherited or acquired mutations in the DNA blueprint. Lastly, we will review new ideas about how to make new RBCs from non-haematopoietic cells, such as iPS cells, or via direct reprogramming. Such knowledge could be harnessed in the future to replace endogenous factories within the bone marrow with exogenous ones so as to secure RBC supply.
It is with great pleasure that I invite you to contribute to this review series in Cells on “Regulation of Erythropoiesis: Building a Red Blood Cell”. The aim of the series is to provide a comprehensive and integrated series of reviews on key topics in erythropoiesis. The series will follow the construction of an RBC from the DNA blueprint to the final supply of an enucleated long-lived cell to the circulation. This process is very commonly derailed by inherited or acquired mutations that disrupt the journey of an RBC from inception to the final enucleated cell that provides three months of oxygen delivery service to the body. I encourage reviews that compare normal with aberrant genetic programs that direct production of normal or defective RBCs, respectively.
Prof. Andrew Perkins
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- erythroid cell ontogeny
- stress erythropoiesis
- EPOR and other signalling pathways
- transcriptional networks
- RNA splicing including intron retention
- translation and Diamond-Blackfan anemia
- heme and erythroid regulation
- globin gene switching
- nuclear compaction and enucleation
- the erythroblastic island