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Optical Tweezers in Studies of Red Blood Cells

1
Optoelectronics and Measurement Techniques Laboratory, University of Oulu, 90570 Oulu, Finland
2
Interdisciplinary Laboratory of Biophotonics, National Research Tomsk State University, 634050 Tomsk, Russia
3
Institute of Engineering Physics for Biomedicine (PhysBio), National Research Nuclear University (MEPhI), 115409 Moscow, Russia
4
Aston Institute of Materials Research, School of Engineering and Applied Science, Aston University, Birmingham B4 7ET, UK
5
School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
*
Authors to whom correspondence should be addressed.
Cells 2020, 9(3), 545; https://doi.org/10.3390/cells9030545
Received: 7 January 2020 / Revised: 5 February 2020 / Accepted: 11 February 2020 / Published: 26 February 2020
(This article belongs to the Special Issue Regulation of Erythropoiesis—Building a Red Blood Cell)
Optical tweezers (OTs) are innovative instruments utilized for the manipulation of microscopic biological objects of interest. Rapid improvements in precision and degree of freedom of multichannel and multifunctional OTs have ushered in a new era of studies in basic physical and chemical properties of living tissues and unknown biomechanics in biological processes. Nowadays, OTs are used extensively for studying living cells and have initiated far-reaching influence in various fundamental studies in life sciences. There is also a high potential for using OTs in haemorheology, investigations of blood microcirculation and the mutual interplay of blood cells. In fact, in spite of their great promise in the application of OTs-based approaches for the study of blood, cell formation and maturation in erythropoiesis have not been fully explored. In this review, the background of OTs, their state-of-the-art applications in exploring single-cell level characteristics and bio-rheological properties of mature red blood cells (RBCs) as well as the OTs-assisted studies on erythropoiesis are summarized and presented. The advance developments and future perspectives of the OTs’ application in haemorheology both for fundamental and practical in-depth studies of RBCs formation, functional diagnostics and therapeutic needs are highlighted. View Full-Text
Keywords: optical tweezers; red blood cells; erythropoiesis; microrheology; cellular biomechanics; pathology optical tweezers; red blood cells; erythropoiesis; microrheology; cellular biomechanics; pathology
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MDPI and ACS Style

Zhu, R.; Avsievich, T.; Popov, A.; Meglinski, I. Optical Tweezers in Studies of Red Blood Cells. Cells 2020, 9, 545. https://doi.org/10.3390/cells9030545

AMA Style

Zhu R, Avsievich T, Popov A, Meglinski I. Optical Tweezers in Studies of Red Blood Cells. Cells. 2020; 9(3):545. https://doi.org/10.3390/cells9030545

Chicago/Turabian Style

Zhu, Ruixue; Avsievich, Tatiana; Popov, Alexey; Meglinski, Igor. 2020. "Optical Tweezers in Studies of Red Blood Cells" Cells 9, no. 3: 545. https://doi.org/10.3390/cells9030545

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