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Cells
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Metabolic Reprogramming in Innate Immunity: Innate Cell Fate and Function
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Metabolic Reprogramming in Innate Immunity: Innate Cell Fate and Function

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: closed (15 December 2021) | Viewed by 9737

Special Issue Editor

Dr. Giuliana Guggino

E-Mail Website
Guest Editor
Department of Promise, Università degli Studi di Palermo, Palermo, Italy
Interests: chronic inflammatory disease; autoimmune and rheumatic disease; innate immunity; immune response; innate lymphoid cells; macrophages; dendritic cells; miRNA; inflammasome; activation pathways
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is a pleasure to present this Special Issue entitled Metabolic Reprogramming in Innate Immunity: Innate Cell Fate and Function.

The role of innate immunity is of fundamental importance in the pathophysiological and pathogenetic processes of various chronic inflammatory diseases. In the last few years, new knowledge has highlighted the potential of this group of cells and the plasticity of their multiple responses. A variety of immune cells contribute to the maintenance of homeostasis against environmental emergencies and happenings. The immune system is categorized into innate and acquired systems, and humans possess a network constituting innate–acquired linkages. In many cases, these cells are responsible for some chronic diseases.

This Special Issue will clarify the role of the immune response in rheumatological diseases and more generally in chronic inflammatory diseases to better understand the mechanisms implemented by the different subsets of cells.

Additionally, new therapeutic frontiers focus not only on the immune system cells but also on the molecules of the different pathways that are activated and became actors in the cascade of events that lead to the inflammatory process and its maintenance.

This collection of works aims to bring together all the necessary evidence on the role of innate immunity and pave the way for new therapeutic possibilities.

We are looking forward to your contributions to this Special Issue.

Prof. Giuliana Guggino
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic inflammatory disease
  • autoimmune and rheumatic disease
  • innate immunity
  • immune response
  • innate lymphoid cells
  • macrophages
  • dendritic cells
  • miRNA
  • inflammasome
  • activation pathways

Published Papers (3 papers)

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Review

21 pages, 1106 KiB  
Review
Metabolic Reprogramming of Innate Immune Cells as a Possible Source of New Therapeutic Approaches in Autoimmunity
by Leila Mohammadnezhad, Mojtaba Shekarkar Azgomi, Marco Pio La Manna, Guido Sireci, Chiara Rizzo, Giusto Davide Badami, Bartolo Tamburini, Francesco Dieli, Giuliana Guggino and Nadia Caccamo
Cells 2022, 11(10), 1663; https://doi.org/10.3390/cells11101663 - 17 May 2022
Cited by 7 | Viewed by 2761
Abstract
Immune cells undergo different metabolic pathways or immunometabolisms to interact with various antigens. Immunometabolism links immunological and metabolic processes and is critical for innate and adaptive immunity. Although metabolic reprogramming is necessary for cell differentiation and proliferation, it may mediate the imbalance of [...] Read more.
Immune cells undergo different metabolic pathways or immunometabolisms to interact with various antigens. Immunometabolism links immunological and metabolic processes and is critical for innate and adaptive immunity. Although metabolic reprogramming is necessary for cell differentiation and proliferation, it may mediate the imbalance of immune homeostasis, leading to the pathogenesis and development of some diseases, such as autoimmune diseases. Here, we discuss the effects of metabolic changes in autoimmune diseases, exerted by the leading actors of innate immunity, and their role in autoimmunity pathogenesis, suggesting many immunotherapeutic approaches. Full article
(This article belongs to the Special Issue Metabolic Reprogramming in Innate Immunity: Innate Cell Fate and Function)
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11 pages, 564 KiB  
Review
Metabolomics: An Emerging Approach to Understand Pathogenesis and to Assess Diagnosis and Response to Treatment in Spondyloarthritis
by Chiara Rizzo, Federica Camarda, Denise Donzella, Lidia La Barbera and Giuliana Guggino
Cells 2022, 11(3), 549; https://doi.org/10.3390/cells11030549 - 04 Feb 2022
Cited by 4 | Viewed by 2196
Abstract
Spondyloarthritis (SpA) is a group of rheumatic diseases whose pathogenesis relies on a complex interplay between genetic and environmental factors. Over the last several years, the importance of the alteration of the gut microbiota, known as dysbiosis, and the interaction of bacterial products [...] Read more.
Spondyloarthritis (SpA) is a group of rheumatic diseases whose pathogenesis relies on a complex interplay between genetic and environmental factors. Over the last several years, the importance of the alteration of the gut microbiota, known as dysbiosis, and the interaction of bacterial products with host immunity have been highlighted as intriguing key players in SpA development. The recent advent of the so called “-omics” sciences, that include metabolomics, opened the way to a new approach to SpA through a deeper characterisation of the pathogenetic mechanisms behind the disease. In addition, metabolomics can reveal potential new biomarkers to diagnose and monitor SpA patients. The aim of this review is to highlight the most recent advances concerning the application of metabolomics to SpA, in particular focusing attention on Ankylosing Spondylitis and Psoriatic Arthritis. Full article
(This article belongs to the Special Issue Metabolic Reprogramming in Innate Immunity: Innate Cell Fate and Function)
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15 pages, 1343 KiB  
Review
Immunity and Nutrition: The Right Balance in Inflammatory Bowel Disease
by Bartolo Tamburini, Marco Pio La Manna, Lidia La Barbera, Leila Mohammadnezhad, Giusto Davide Badami, Mojtaba Shekarkar Azgomi, Francesco Dieli and Nadia Caccamo
Cells 2022, 11(3), 455; https://doi.org/10.3390/cells11030455 - 28 Jan 2022
Cited by 14 | Viewed by 4040
Abstract
Inflammatory bowel disease (IBD) is an increasingly urgent medical problem that strongly impairs quality of life for patients. A global rise in incidence has been observed over the last few decades, with the highest incidence rates recorded in North America and Europe. Still, [...] Read more.
Inflammatory bowel disease (IBD) is an increasingly urgent medical problem that strongly impairs quality of life for patients. A global rise in incidence has been observed over the last few decades, with the highest incidence rates recorded in North America and Europe. Still, an increased incidence has been reported in the last ten years in newly industrialized countries in Asia, including China and India, both with more than one billion inhabitants. These data underline that IBD is an urgent global health problem. In addition, it is estimated that between 20% and 30% of IBD patients will develop colorectal cancer (CRC) within their lifetime and CRC mortality is approximately 50% amongst IBD patients. Although the exact etiology of IBD is still being defined, it is thought to be due to a complex interaction between many factors, including defects in the innate and adaptive immune system; microbial dysbiosis, i.e., abnormal levels of, or abnormal response to, the gastrointestinal microbiome; a genetic predisposition; and several environmental factors. At present, however, it is not fully understood which of these factors are the initiators of inflammation and which are compounders. The purpose of this review is to analyze the complex balance that exists between these elements to maintain intestinal homeostasis and prevent IBD or limit adverse effects on people’s health. Full article
(This article belongs to the Special Issue Metabolic Reprogramming in Innate Immunity: Innate Cell Fate and Function)
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