Cellular and Molecular Mechanisms Governing Liver Pathophysiology

Dear Colleagues,

Liver functions are finely tuned by environmental stimuli, which translate into adaptative cellular behaviors partly through modulation of their transcriptome. While these mechanisms have historically been studied in detailed in hepatocytes, current efforts also aim to better define how the activities of additional liver cell-types are controlled. Indeed, cells of the non-parenchymal fraction and their inter-cellular cross-talks with hepatocytes are increasingly being defined as central components in healthy and injured liver. In this context, liver physiological activities, regenerative capacity, and alterations in acute or chronic conditions are driven by coordinated molecular changes in the different liver cell-types. These mechanisms are now investigated at (multi-)omics levels, allowing us to obtain novel insights into the molecular control of liver cells’ activities.

The purpose of this Special Issue is to highlight recent findings that shed light on how the functions of hepatocytes and non-parenchymal cells are controlled at the molecular level to trigger adaptative or maladaptive responses in liver pathophysiology. We welcome the submission of both original research articles and reviews.

Dr. Jérôme Eeckhoute
Guest Editor

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