New Insights into Oxidative Stress and Inflammation in Diabetes

Dear Colleagues,

Amassing evidence has described a coordinated crosstalk between inflammation and oxidative stress in the development of metabolic dysfunction, including diabetes and diabetes-associated complications. Increased prevalence of insulin resistance (a prediabetes condition) and diabetes has reached an epidemic proportion all over the world. According to the WHO, the global diabetes epidemic currently affects over 400 million adults, and the number is expected to rise to 550 million by the year 2030. Progressive deterioration in metabolic control with existing therapeutic modalities necessitates better understanding and newer therapeutic interventions for the effective management of diabetes. Oxidative stress and inflammation affects a multitude of cellular responses in various organs, and the progression of insulin resistance is known to be associated with chronic systemic inflammation and increased oxidative stress. The positive feedback cycle involving the abnormal formation of reactive oxygen species, changes in inflammatory gene expression profile, and the progression of insulin resistance contributes to several diabetes-associated complications, including cardiovascular diseases, nephropathy, neuropathy, retinopathy, urological diseases, and cancer. This Special Issue aims to highlight bidirectional relationships between inflammation and oxidative stress and their role in the pathophysiology and treatment of diabetes.

Specifically, this Issue entitled “New Insights into Oxidative Stress and Inflammation in Diabetes” solicits original research and review articles on topics including but not restricted to the role and contribution of oxidative stress and inflammation in diabetes. Research related to metabolism may be broadly defined (e.g., biomarkers and processes related to metabolic disorders; interventions or lifestyle factors such as diet and exercise; cellular metabolism and mitochondrial function), and all manuscripts should include the measurement of (or discussion of for reviews) at least one aspect of inflammation or oxidative stress.

Prof. In-Kyu Lee
Dr. Dipanjan Chanda
Guest Editors

Manuscript Submission Information

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