Special Issue "Novel Insights on Cerebrospinal Fluid Research"

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 31 March 2021.

Special Issue Editors

Prof. Dr. Thomas Skripuletz
Guest Editor
Department of Neurology,Hannover Medical School, Hannover, Germany
Interests: immune mediated neuropathies; Neuro-Sjögren; multiple sclerosis; neuroimmuno-oncology; neuroinfectious diseases; neuroimmunology
Dr. Alexandra Neyazi
Guest Editor
Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany
Interests: psychoneuroimmunology; multiple sclerosis; affective disorders; cerebrospinal fluid research; epigenetics; psychiatric biomarkers

Special Issue Information

Dear Colleagues,

Cerebrospinal fluid (CSF) analysis is an essential diagnostic tool in a high number of neurological and psychiatric diseases. This includes predominantly autoimmune, infectious, and neurodegenerative diseases of the central and peripheral nervous system. However, psychiatrists increasingly are involved in this relevant research topic. 

Since 2017, CSF oligoclonal bands have been used as a part of the McDonald criteria to diagnose multiple sclerosis. This new diagnostic approach has led to a relevant change in the sensitivity of the criteria to diagnose multiple sclerosis. In the last two years, several groups have shown that multiple sclerosis can be now diagnosed more frequently at the time of first clinical relapse, underlining the importance of incorporating CSF analysis.

The important role of CSF examination and disease monitoring has arisen in further diseases, including autoimmune encephalitis driven by autoantibodies directed against neuronal structures such as the N-methyl-D-aspartate (NMDA) receptor. Patients with such diseases are treated in both neurology and psychiatry. Still, further experimental research is needed to obtain a better understanding of this severe disease entity.

This Special Issue of Cells is dedicated to the complete experimental research on CSF in neurologic and psychiatric diseases. There is a need to identify new biomarkers, including cellular research for most neurological and psychiatric diseases. We look forward for your contribution to this intensely developing area of research.

Prof. Dr. Thomas Skripuletz
Dr. Alexandra Neyazi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • CSF biomarker
  • kappa free light chains (KFLC)
  • cellular research
  • biomarker
  • neuroimmunology
  • psychoneuroimmunology
  • infection
  • multiple sclerosis
  • psychiatry
  • autoimmune disease

Published Papers (1 paper)

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Open AccessArticle
Tick-Borne Encephalitis: A Differential Pattern of Intrathecal Humoral Immune Response and Inflammatory Cell Composition Compared with Other Viral CNS Infections
Cells 2020, 9(10), 2169; https://doi.org/10.3390/cells9102169 - 25 Sep 2020
To investigate whether and how cerebrospinal fluid (CSF) findings can contribute to distinguish tick-borne encephalitis (TBE) from herpes simplex virus (HSV) and varicella zoster virus (VZV) induced central nervous system (CNS) infections (HSV-I, VZV-I). Chart review and identification of TBE, HSV- I, and [...] Read more.
To investigate whether and how cerebrospinal fluid (CSF) findings can contribute to distinguish tick-borne encephalitis (TBE) from herpes simplex virus (HSV) and varicella zoster virus (VZV) induced central nervous system (CNS) infections (HSV-I, VZV-I). Chart review and identification of TBE, HSV- I, and VZV-I was carried out, fulfilling the following criteria: (1) clinical signs of encephalitis and/or meningitis, (2) complete CSF analysis and confirmed viral etiology by either PCR or antibody testing in CSF, (3) hospitalized patients, and (4) available brain magnetic resonance imaging (MRI). Fifty-nine patients with 118 CSF/serum pairs were included. These comprised 21 with TBE (35 CSF/serum pairs), 20 (40 CSF/serum pairs) with HSV-I, and 18 (43 CSF/serum pairs) with VZV-I. In contrast to HSV-I and VZV-I, CSF cell differentiation in TBE showed more often an increased (>20%) proportion of granulocytes (p < 0.01) and a more frequent quantitative intrathecal IgM synthesis (p = 0.001 and p < 0.01, respectively), while the second was even more pronounced when follow-up CSF analyses were included (p < 0.001). CSF findings help to distinguish TBE from other viral infections. In cases with CSF pleocytosis and a positive history for a stay in or near an endemic area, TBE antibodies in CSF and serum should be determined, especially if granulocytes in CSF cell differentiation and/or an intrathecal IgM synthesis is present. Full article
(This article belongs to the Special Issue Novel Insights on Cerebrospinal Fluid Research)
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