Special Issue "Molecular and Cellular Mechanisms of Parkinson's Disease"
Deadline for manuscript submissions: 31 January 2021.
Interests: Parkinson’s disease; atypical Parkinson syndromes; dystonia; autonomic nervous system; botulinum toxin
Special Issues and Collections in MDPI journals
Parkinson’s disease is a disease for which we have attained a massive gain in knowledge within the last few decades, and for which the number of publications has increased as in hardly any other area of medicine. We are fortunate to have many effective medications at our disposal for this disease. The central issue here has been the substantia nigra, and the deficiency in levodopa has been the pivotal focus for therapy. In the last two decades, however, we have learned that emphasis on these concepts offers only limited benefits and may in fact be detrimental for further progress in research. To be precise, the substantia nigra is neither the origin nor the end point of the degenerative process, and furthermore dopaminergic therapy is merely a symptomatic intervention. Of course, all further progress is a factor of our basic hypotheses, but these have to be substantiated as to their validity. In Parkinson’s diagnostics and therapy, we have arrived at something of a stalemate: many new findings are truly spectacular, but not yet the final answer to all our questions. As clinicians, of course, we tend to target quick solutions, but so do our patients, and these quick solutions are still very illusive. For this reason, we have to return to the situation at the historical start of work on Parkinson’s and take a good look at current gaps in knowledge in order to work them out scientifically. For this reason, we have decided to put out a Special Issue entitled “Molecular and Cellular Mechanisms of Parkinson’s Disease”. We are deliberately not working on a new and comprehensive model in this Issue, but intend to outline the current status of different aspects so that the large spectrum of findings can be seen and so that some hints can be gleaned as to just where we might profitably pursue new fields of research and where we should avoid some potential dead-ends. Put metaphorically, if I have become lost in a city it is more helpful to return to the starting point and not just to rely on keeping to the obviously wrong route taken. So, we want to meet at the market and trade our current awareness.
Prof. Wolfgang Jost
Manuscript Submission Information
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- Parkinson’s disease