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Review

The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson’s Disease

1
Translational Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 4365 Esch-sur-Alzette, Luxembourg
2
Biospecimen Research Group, Integrated Biobank of Luxembourg, Luxembourg Institute of Health (LIH), 3531 Dudelange, Luxembourg
3
Enzymology & Metabolism, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 4365 Esch-sur-Alzette, Luxembourg
4
RIKEN Outpost Laboratory, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 4365 Esch-sur-Alzette, Luxembourg
5
Parkinson Research Clinic, Centre Hospitalier de Luxembourg (CHL), 1210 Luxembourg (Belair), Luxembourg
6
Transversal Translational Medicine, Luxembourg Institute of Health (LIH), 1445 Strassen, Luxembourg
*
Authors to whom correspondence should be addressed.
Academic Editor: Wolfgang Jost
Cells 2021, 10(2), 347; https://doi.org/10.3390/cells10020347
Received: 28 December 2020 / Revised: 27 January 2021 / Accepted: 3 February 2021 / Published: 7 February 2021
(This article belongs to the Collection Molecular and Cellular Mechanisms of Parkinson's Disease)
DJ-1 is a multifunctional protein associated with pathomechanisms implicated in different chronic diseases including neurodegeneration, cancer and diabetes. Several of the physiological functions of DJ-1 are not yet fully understood; however, in the last years, there has been increasing evidence for a potential role of DJ-1 in the regulation of cellular metabolism. Here, we summarize the current knowledge on specific functions of DJ-1 relevant to cellular metabolism and their role in modulating metabolic pathways. Further, we illustrate pathophysiological implications of the metabolic effects of DJ-1 in the context of neurodegeneration in Parkinson´s disease. View Full-Text
Keywords: DJ-1; Parkinson´s disease; metabolism DJ-1; Parkinson´s disease; metabolism
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MDPI and ACS Style

Mencke, P.; Boussaad, I.; Romano, C.D.; Kitami, T.; Linster, C.L.; Krüger, R. The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson’s Disease. Cells 2021, 10, 347. https://doi.org/10.3390/cells10020347

AMA Style

Mencke P, Boussaad I, Romano CD, Kitami T, Linster CL, Krüger R. The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson’s Disease. Cells. 2021; 10(2):347. https://doi.org/10.3390/cells10020347

Chicago/Turabian Style

Mencke, Pauline, Ibrahim Boussaad, Chiara D. Romano, Toshimori Kitami, Carole L. Linster, and Rejko Krüger. 2021. "The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson’s Disease" Cells 10, no. 2: 347. https://doi.org/10.3390/cells10020347

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