Dear Colleagues,

Neuroinflammation of the central nervous system (CNS) is a primer of normal brain aging and many neurological disorders, including neurodegenerative disease and chronic pain states. It is well known that activation of glial cells, paralleled by energetic failure and ROS production, is a key part of the inflammatory process, boosting maladaptive synaptic changes and also cell death; however, metabolic control of inflammosome through glucose and lipid metabolism in CNS is essential for maintaining homeostasis and neural function in health and disease. To sustain neuronal function, activated glial cells undergo metabolic reprogramming (from glucose to the lipidic metabolism) that activates Toll-like receptor-4 (TLR4), caspases, NLPR1-3, sustaining neuroinflammation and leading to cell death. Therefore, it is conceivable that the overall metabolic state influences brain function and represents a new putative target for preserving long-term brain wellness and preventing neurodegenerative disorders.

Dr. Giovanni Cirillo
Guest Editor

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• lipid rafts
• glucidic metabolism
• neuroinflammation
• reactive gliosis
• maladaptive plasticity