Special Issue "Neuroplasticity of Central Nervous System in Health and Disease"

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editor

Dr. Giovanni Cirillo
E-Mail Website
Guest Editor
1) Division of Human Anatomy, Department of Mental, Physical Health and Preventive Medicine;
2) Division of Neurology and Neurophysiopathology, University of Campania Luigi Vanvitelli, Naples, Italy
Interests: neuromuscular disorders; dysimmune peripheral neuropathies; myasthenia gravis; electroneuromyography; evoked potentials; transcranial magnetic stimulation
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Special Issue Information

Dear Colleagues,

Neuroplasticity represents the key feature of the central nervous system (CNS) and includes both short- and long-term adaptive synaptic changes that, in turn, modulate the activity of brain networks underlying higher brain functions. Recent advances strongly support the role of activated glial cells in the perturbation of synaptic plasticity. This condition, called maladaptive synaptic plasticity, represents the final result of a cascade of events (neuroinflammation, failure of neurovascular coupling, changes of neurotransmitters homeostasis, failure of rescue mechanisms, metabolic/mitochondrial dysfunction) leading to disruption of the complex neuroglial networks underlying neural homeostasis and connectivity within brain circuits. In this new light, inflammatory, neurodegenerative, and also psychiatric disorders might be primarily regarded as disorders of neuroglial-based synaptic plasticity, opening new perspectives into the complex mechanisms of disease. Accordingly, the possibility to directly modulate synaptic functions and plasticity through induction of both short- and long-term neurobiological after-effects with non-invasive brain stimulation techniques is paving the way for new therapeutic strategies in treating neuropsychiatric disorders. Unraveling the complex brain structure and function at each level, from basic mechanisms to dynamic circuitry, will allow understanding of synaptic plasticity and higher brain functions and how their perturbations contribute to brain diseases.

Dr. Giovanni Cirillo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • synaptic plasticity
  • glial cells
  • neuroglial homeostasis
  • maladaptive plasticity
  • neuropsychiatric disorders
  • non-invasive brain stimulation techniques

Published Papers

This special issue is now open for submission.
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