Cellular and Molecular Mechanisms of Wound Repair

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 388

Special Issue Editor


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Dipartimento di Scienze e Innovazione Tecnologica (DiSIT), University of Piemonte Orientale "Amedeo Avogadro", Viale Teresa Michel 11, 15121 Alessandria, Italy
Interests: honey; natural products; propolis; confocal microscopy; cell signaling; aquaporins; wound repair; tissue regeneration
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Special Issue Information

Dear Colleagues,

A coordinated sequence of cellular and molecular activities is required for the complicated and dynamic process of wound healing in order to restore tissue integrity. At the molecular level, numerous signaling molecules, including cytokines, chemokines, and growth factors, coordinate the interactions between different cell types, including immune cells, fibroblasts, keratinocytes, and endothelial cells. Important processes like angiogenesis, cell migration, proliferation, and extracellular matrix deposition are all regulated by this complex interaction. Developing cutting-edge therapeutic approaches, such as regenerative medicine and bioengineered skin substitutes, requires an understanding of the cellular and molecular principles underlying wound healing.

Thus, we extend this invitation for you to submit a review or your original research findings to our Special Issue, titled "Cellular and Molecular Mechanisms of Wound Repair".

Dr. Elia Ranzato
Guest Editor

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Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • wound healing
  • cellular mechanisms
  • tissue remodeling
  • growth factors
  • extracellular matrix
  • tissue regeneration

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Published Papers (1 paper)

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Research

20 pages, 5620 KB  
Article
Multispectral Pulsed Photobiomodulation Enhances Re-Epithelialization via Keratinocyte Activation in Full-Thickness Skin Wounds
by Joo Hyun Kim, Delgerzul Baatar, Myung Jin Ban, Ji Won Son, Jihye Choi, Chan Hee Gil, Min-Kyu Kim, Sung Sik Hur, Jung Eun Kim and Yongsung Hwang
Cells 2025, 14(18), 1415; https://doi.org/10.3390/cells14181415 - 10 Sep 2025
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Abstract
Chronic wound healing is a complex and tightly regulated process requiring coordinated epithelial and stromal regeneration. Photobiomodulation (PBM) using low-level red light-emitting diode (LED) therapy has emerged as a non-invasive approach to enhancing skin repair. In this study, we evaluated the therapeutic efficacy [...] Read more.
Chronic wound healing is a complex and tightly regulated process requiring coordinated epithelial and stromal regeneration. Photobiomodulation (PBM) using low-level red light-emitting diode (LED) therapy has emerged as a non-invasive approach to enhancing skin repair. In this study, we evaluated the therapeutic efficacy of a pulsed, multi-wavelength LED system on full-thickness excisional wound healing in a normal murine model. Daily LED treatment significantly accelerated wound closure, promoted re-epithelialization, and improved dermal architecture. Histological and immunohistochemical analyses revealed enhanced epidermal stratification, reduced inflammation, and improved collagen organization. Molecular profiling demonstrated increased expression of proliferation marker Ki67, keratins CK14 and CK17, and extracellular matrix-related genes including MMPs, Col1a1, and Col3a1. In vitro assays using HaCaT keratinocytes showed accelerated scratch wound closure and cytoskeletal remodeling following PBM exposure. These findings suggest that pulsed PBM promotes coordinated epithelial regeneration and matrix remodeling, highlighting its potential as a tunable and effective therapeutic modality for accelerating cutaneous wound healing under physiological conditions. Full article
(This article belongs to the Special Issue Cellular and Molecular Mechanisms of Wound Repair)
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