Extracellular Vesicle-Based Therapeutics: Current Advances and Future Perspectives

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 31 May 2025 | Viewed by 2892

Special Issue Editor


E-Mail Website
Guest Editor
1. Laboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA 20110, USA
2. American Type Culture Collection, Manassas, VA 20110, USA
Interests: stem cell culture; stem cell-derived extracellular vesicles; 3D cell culture; regenerative medicine

Special Issue Information

Dear Colleagues,

The field of extracellular vesicles (EVs) and, more specifically, EV-based therapeutics, is expanding rapidly. Human and animal stem cells represent rich sources of EVs, and these EVs have demonstrated therapeutic applications across many different pathologies and tissue types due to their multi-functional reparative properties. Recent technological advances have further improved EV production/manufacturing, EV purification, and EV characterization. Importantly, these improvements can be leveraged to boost the therapeutic potential of EVs.

This Special Issue will focus on topics including, but not limited to, methods for enhanced EV production, including the isolation and characterization of EV subpopulations; strategies for maximizing EV potency and functionality; advanced assays for identification of EV-associated biological cargo; and various in vitro and in vivo models for cellular and tissue repair.

Dr. Heather Branscome
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • extracellular vesicles (EVs)
  • stem cells
  • mesenchymal stem cells
  • in vitro cellular repair models
  • animal models for repair and or/tissue regeneration
  • cell-free therapy

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Review

27 pages, 1110 KiB  
Review
Targeting of Extracellular Vesicle-Based Therapeutics to the Brain
by Anastasia Williams, Heather Branscome, Fatah Kashanchi and Elena V. Batrakova
Cells 2025, 14(7), 548; https://doi.org/10.3390/cells14070548 - 4 Apr 2025
Viewed by 1281
Abstract
Extracellular vesicles (EVs) have been explored as promising vehicles for drug delivery. One of the most valuable features of EVs is their ability to cross physiological barriers, particularly the blood–brain barrier (BBB). This significantly enhances the development of EV-based drug delivery systems for [...] Read more.
Extracellular vesicles (EVs) have been explored as promising vehicles for drug delivery. One of the most valuable features of EVs is their ability to cross physiological barriers, particularly the blood–brain barrier (BBB). This significantly enhances the development of EV-based drug delivery systems for the treatment of CNS disorders. The present review focuses on the factors and techniques that contribute to the successful delivery of EV-based therapeutics to the brain. Here, we discuss the major methods of brain targeting which includes the utilization of different administration routes, capitalizing on the biological origins of EVs, and the modification of EVs through the addition of specific ligands on to the surface of EVs. Finally, we discuss the current challenges in large-scale EV production and drug loading while highlighting future perspectives regarding the application of EV-based therapeutics for brain delivery. Full article
Show Figures

Graphical abstract

15 pages, 656 KiB  
Review
Mesenchymal Stem-Cell-Derived Exosomes as Novel Drug Carriers in Anti-Cancer Treatment: A Myth or Reality?
by Carl Randall Harrell, Ana Volarevic, Valentin Djonov and Vladislav Volarevic
Cells 2025, 14(3), 202; https://doi.org/10.3390/cells14030202 - 29 Jan 2025
Cited by 1 | Viewed by 1263
Abstract
Although cancer therapy has significantly advanced in recent decades, patients and healthcare professionals are still quite concerned about adverse effects due to the non-targeted nature of currently used chemotherapeutics. Results obtained in a large number of recently published experimental studies indicated that mesenchymal [...] Read more.
Although cancer therapy has significantly advanced in recent decades, patients and healthcare professionals are still quite concerned about adverse effects due to the non-targeted nature of currently used chemotherapeutics. Results obtained in a large number of recently published experimental studies indicated that mesenchymal stem-cell-derived exosomes (MSC-Exos), due to their biocompatibility, ability to cross biological barriers, and inherent targeting capabilities, could be used as a promising drug-delivery system for anti-cancer therapies. Their lipid bilayer protects cargo of anti-cancer drugs, making them excellent candidates for the delivery of therapeutic agents. MSC-Exos could be engineered to express ligands specific for tumor cells and, therefore, could selectively deliver anti-cancer agents directly in malignant cells, minimizing side effects associated with chemotherapeutic-dependent injury of healthy cells. MSC-Exos can carry multiple therapeutic agents, including anti-cancer drugs, micro RNAs, and small bioactive molecules, which can concurrently target multiple signaling pathways, preventing tumor growth and progression and overcoming resistance of tumor cells to many standard chemotherapeutics. Accordingly, in this review article, we summarized current knowledge and future perspectives about the therapeutic potential of MSCs-Exos in anti-cancer treatment, opening new avenues for the targeted therapy of malignant diseases. Full article
Show Figures

Figure 1

Back to TopTop