The Role of Adipose-Derived Stem Cells in Neural Regeneration

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 980

Special Issue Editors


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Guest Editor
Klinikum der Universität Regensburg und Medizinische Fakultät, Regensburg, Germany
Interests: reconstructive surgery; hand surgery; peripheral nerve surgery; extremity reconstruction; pressure sore therapy

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Guest Editor
Department of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, 93053 Regensburg, Germany
Interests: reconstructive surgery; breast reconstruction; facial reanimation; surgical skin tumor therapy; aesthetic surgery
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Guest Editor
Department of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany
Interests: mesenchymal stem cells; autologous fat grafting; regeneration; adipose tissue
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Peripheral nerve surgery has experienced significant advancements in recent decadesthanks to progress in peripheral nerve transfers and the refinement of microsurgical techniques. However, surgical options are still primarily centered on restoring nerve continuity. There is mounting evidence indicating substantial potential for the next phase to encompass the targeted manipulation of nerve regeneration by impacting cellular or hormonal microenvironments. Hence, this Special Issue focuses on fundamental aspects that could foster positive outcomes in nerve regeneration. Manuscripts exploring the analysis and modulation of cellular nerve regeneration via innovative methods in cell cultures, as well as the precise application of growth factors, exosomes, and stem cells, are encouraged to be submitted.

Prof. Dr. Silvan Maximilian Klein
Prof. Dr. Alexandra M. Anker
Dr. Oliver Heinrich Felthaus
Guest Editors

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Keywords

  • neural regeneration
  • mesenchymal stem cells
  • peripheral nerve injury
  • regenerative medicine
  • growth factors
  • cytokines
  • exosomes

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Published Papers (1 paper)

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Research

20 pages, 13806 KiB  
Article
Application of Mesenchymal Stem Cell-Derived Schwann Cell-like Cells Spared Neuromuscular Junctions and Enhanced Functional Recovery After Peripheral Nerve Injury
by Yu Hwa Nam, Ji-Sup Kim, Yoonji Yum, Juhee Yoon, Hyeryung Song, Ho-Jin Kim, Jaeseung Lim, Saeyoung Park and Sung-Chul Jung
Cells 2024, 13(24), 2137; https://doi.org/10.3390/cells13242137 - 23 Dec 2024
Viewed by 660
Abstract
In general, the nerve cells of the peripheral nervous system regenerate normally within a certain period after the physical damage of their axon. However, when peripheral nerves are transected by trauma or tissue extraction for cancer treatment, spontaneous nerve regeneration cannot occur. Therefore, [...] Read more.
In general, the nerve cells of the peripheral nervous system regenerate normally within a certain period after the physical damage of their axon. However, when peripheral nerves are transected by trauma or tissue extraction for cancer treatment, spontaneous nerve regeneration cannot occur. Therefore, it is necessary to perform microsurgery to connect the transected nerve directly or insert a nerve conduit to connect it. In this study, we applied human tonsillar mesenchymal stem cell (TMSC)-derived Schwann cell-like cells (TMSC-SCs) to facilitate nerve regeneration and prevent muscle atrophy after neurorrhaphy. The TMSC-SCs were manufactured in a good manufacturing practice facility and termed neuronal regeneration-promoting cells (NRPCs). A rat model of peripheral nerve injury (PNI) was generated and a mixture of NRPCs and fibrin glue was transplanted into the injured nerve after neurorrhaphy. The application of NRPCs and fibrin glue led to the efficient induction of sciatic nerve regeneration, with the sparing of gastrocnemius muscles and neuromuscular junctions. This sparing effect of NRPCs toward neuromuscular junctions might prevent muscle atrophy after neurorrhaphy. These results suggest that a mixture of NRPCs and fibrin glue may be a therapeutic candidate to enable peripheral nerve and muscle regeneration in the context of neurorrhaphy in patients with PNI. Full article
(This article belongs to the Special Issue The Role of Adipose-Derived Stem Cells in Neural Regeneration)
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