Cellular Function of Transcriptional Inhibitors and Repressors in Physiology and Pathology

Dear Colleagues, 

Regulation of gene expression by transcription is essential to cell differentiation, development, homeostasis, and adaptive response to stress. Transcription factors are DNA binding proteins that are essential to the initiation and the control of the rate of gene transcription. The repression of transcription is also crucial to the prevention of inappropriate gene expression. Defects in the repression of gene expression can result in developmental disorders and diseases. To this end, the repression of gene expression is composed of various mechanisms such as non-coding RNA, epigenetic modification of chromosomes, and transcriptional repression. Of these mechanisms, the inhibition of transcription is less well-studied. In this Special Issue, we would like to focus on the pathophysiological roles of transcriptional inhibitors or repressors. Transcriptional repressors are proteins that negatively regulate transcriptional factors, DNA binding proteins, toxins, or chemical drugs. We hope that the papers collected in this Special Issue will contribute to our understanding of transcriptional repression and provide us with clues for developing new therapies.

Dr. Andrés Daniel Maturana
Guest Editor

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• transcriptional repression
• gene expression
• cell physiology