Mechanisms of Neuronal Autophagy

Dear Colleagues,

Autophagy is a self-degrading cellular process that is tightly regulated by multiple signaling pathways regulated by internal and external stimuli. Macroautophagy, microautophagy, and chaperone-mediated autophagy are the main types of autophagy, macroautophagy being the best-studied mechanism. Dysfunctional autophagy in the brain has been associated with major neurodegenerative diseases associated with aging, such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, among others. However, it is not clear if defects in brain autophagy play a causative role in age-related neurodegeneration, and the mechanisms that govern autophagy in different types of neurons are not fully understood.

This Special Issue aims to compile recent evidence of novel mechanisms that regulate autophagy in neurons, differences in autophagy regulation between different types of neurons, regulation of neuronal autophagy by different brain cell types, sex-biased neuronal autophagy, and autophagy-related signaling pathways altered with brain aging.

Dr. Jose Felix Moruno Manchon
Guest Editor

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