Adipose-Derived Mesenchymal Stem Cells: Current Uses and Future Perspectives for Vascular Applications
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 3107
Special Issue Editor
Special Issue Information
Dear Colleagues,
Adipose-derived mesenchymal stem cells (AdMSCs), also known as adipose stromal cells, are among the most attractive cell types for cellular therapy. These cells are easily obtained from the patients and can be isolated and expanded in numbers sufficient for clinical applications. Pre-clinical studies and clinical trials revealed that systemic infusion of AdMSCs produces therapeutic effects in multiple pathologies. The primary mechanism of AdMSC therapeutic effects is attributed to their immunomodulatory activity. At the same time, analysis of the AdMSC niche in adipose tissue revealed that these cells are localized either peri-endothelial or in the adventitia media. AdMSCs strongly support endothelial cell proliferation and tubulogenesis in vitro and functional vessel formation in vivo, and these effects were due to AdMSC paracrine and juxtacrine activity. Vascularization of ischemic tissues, after ischemic insult or 2nd/3rd degree burns, and tissue engineered constructs are important areas of vascular medicine and biotechnology that have not yet been well addressed. Limited sources of endothelial and mural cells inhibit the progress in these areas. With the discovery of AdMSCs as a source of mural cells, there is a big opportunity to advance this field. This Topic aims to highlight the latest advances in AdMSCs used to study the principles of vasculogenesis and angiogenesis, to fabricate organs on the chip, and for tissue vascularization where AdMSCs engaged in vessel formation and stabilization. Studies comparing the vasculo-/angiogenic characteristics of AdMSCs with MSCs from other sources, as well as with mature mural cells (pericytes and smooth muscle cells) and fibroblasts are encouraged. Studies addressing the effects of chronic conditions (smoking, alcohol abuse, diabetes, obesity, metabolic syndrome, and systemic inflammation) on AdMSC angiogenic activities are welcome. We invite you to contribute original research papers, short communications, and mini-reviews.
Dr. Dmitry O. Traktuev
Guest Editor
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Keywords
- adipose stem/stromal cells
- endothelial–MSC interaction
- vasculogenesis
- angiogenesis
- blood perfusion
- smooth muscle cell
- organ-on-a-chip
- pericyte
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