Mesenchymal Stem Cell-Derived Extracellular Vesicles as Therapeutics, 2nd Edition
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Gene and Cell Therapy".
Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 2341
Special Issue Editors
Interests: regenerative medicine; mesenchymal stromal cells; osteoarthritis; extracellular vesicles; miRNA
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mesenchymal stromal cells (MSCs) have gained attention in the field of regenerative medicine. MSCs’ differentiation potential, together with their paracrine properties, has made them a crucial option for tissue healing and repair. MSCs’ paracrine properties rely on the release of soluble factors and extracellular vesicles (EVs) such as exosomes and microvesicles. EVs’ origin is mainly endosomal, and they shuttle a cargo defined by several active molecules such as miRNA, mRNA, lipids and proteins that are transferred from their original cells to target cells. In the last decade, EVs have been postulated as crucial players for the therapeutic effect of MSCs in several in vitro and in vivo disease models. Moreover, a number of clinical trials using MSC-EVs have been started, covering cancer, neurological diseases, diabetes and COVID-19. Hence, MSC-EVs may be envisioned as a cell-free therapy in regenerative medicine and all those diseases where tissue healing is needed. Nevertheless, a thorough characterization of the cargo fingerprint associated with the MSC source and an explanation of MSCs’ properties are still largely missing. Therefore, the aim of this Special Issue is to collect reports from in vitro studies to clinical trials, thereby shedding light on MSC-EV features at both the physiological and molecular levels.
Dr. Enrico Ragni
Dr. Daniela Boselli
Guest Editors
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Keywords
- mesenchymal stromal cells
- extracellular vesicles
- regenerative medicine
- miRNA
- lipids
- cytokines
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