Mathematical Modeling of Cell Crosstalk
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Biophysics".
Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 2418
Special Issue Editors
Interests: statistical and quantitative genetics in medicine; agriculture and evolution
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Many biological processes underlying phenotypic or disease formation are determined by the mechanisms of how neighbouring and distant cells crosstalk to form cellular networks. In particular, cancer cells communicate bi-directionally with their neighboring cancer cells and with the tumor microenvironment through interconnected feedback loops that generate many emergent outcomes for the tumor. Immune cells participate in many types of physical or biological interactions with other immune and nonimmune lineages, facilitating tissue repair, phagocytosis and cell death. Genomic technologies can dissect individual cell state at high resolution, which has afforded an unprecendented opportunity to revolutionize our understanding of cellular functions. However, to more precisely identify, quantify, and characterize cell-cell interactions and their impacts on fundamental organismal processes, it is sorely needed to integrate sophistaicated mathematical models into these genomic technologies.
This issues will publish a collection of mathemetical and computational models that can study how cells communicate with each other across an organism’s diverse cell types and tissues and how cell crosstalk mediates the outcome of diseases. Written by a group of experienced researchers who stand at the frontiers of computational cell biology, these models can faciliate our understanding of the complexities of cell signaling, differentiation, and proliferation towards the formation of complex traits and diseases. Coupled with the ever-expanding availability of single-cell analysis data, these models will find their immediate implications for modelling important biological processes, such as tumour-immune dynamics and germ-soma crosstalk, with the ultimate goal of improving human health and reproduction
Prof. Dr. Rongling Wu
Dr. Song Wu
Guest Editors
Manuscript Submission Information
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Keywords
- cell-cell interaction
- single-cell analysis
- mathematical model
- omics data
- gene regulatory networks
