Special Issue "The Molecular Mechanisms behind Mast Cell Allergic and Innate Immune Responses"
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 8257
Exocytosis is the final step in the secretory pathway. In professional secretory cells, including neurons, endocrine, exocrine and cells of the immune system, the secretory pathway to release proteins and other materials destined for export from cells, in a regulated fashion, following receipt of a signal applied at the cell surface. As such, exocytosis serves a central role in cell communication with its environment and the coordination of its cellular functions. In immune cells, such as mast cells, regulated exocytosis mediates their immediate response, which leads to the release of a variety of inflammatory mediators that are pre-formed and stored in cytoplasmic secretory granules (SGs). Therefore, mast cell exocytosis plays a central role in mediating mast cell pathological responses in allergy and anaphylaxis, and their physiological innate immune responses, in their capacity as sentinel cells of the immune system. Yet, the mechanisms that underlie mast cell degranulation are still not entirely understood. Questions that await further investigation concern the mechanism behind the biogenesis of the mast cell SGs; do they share mechanisms with other lysosome-related organelles, or rather, with other secretory cells? Their precise mechanisms of coupling signaling with secretion and the precise role of the cytoskeleton, actin and microtubules in controlling exocytosis are yet to be investigated. Given the heterogeneity of mast cells, the heterogeneity of their SGs, the multiple stimuli mast cells respond to and the fact that mast cells can utilize distinct modes of exocytosis to release their SG content, it is envisioned that the mechanisms that control mast degranulation and the release of their SG content are complex and not necessarily unifying. This Special Issue aims to create a collection of original research and review articles that address different aspects of mast cell secretion.
Prof. Dr. Ronit Sagi-Eisenberg
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- secretory granules
- stimulus–secretion coupling