Aging in Neuronal Networks

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 2103

Special Issue Editors


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Guest Editor
Departamento de Anatomía, Histología y Neurociencia, Facultad de Medicina, Universidad Autonoma de Madrid, 28029 Madrid, Spain
Interests: neurophysiology; cholinergic system; barrel cortex; somatosensory system; IGF-I; orexin; EEG; aging; diabetes; sleep
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Guest Editor
Facultad de Ciencias de la Salud, Universidad Francisco de Vitoria, Pozuelo de Alarcón, 28223 Madrid, Spain
Interests: Alzheimer disease; amyotrophic lateral sclerosis

Special Issue Information

Dear Colleagues,

Healthy aging is accompanied by a decline in cortical activity with an impairment in cognitive information processing. Both animal and human studies have shown that aging is associated with alterations in synaptic transmission and structural synaptic changes, as well as a consistent loss of synaptic connections. Many of the studies that have been carried out so far have focused on demonstrating that there are changes in the synaptic and intrinsic properties of neurons. However, less is known about the alterations at the neuronal network level. Healthy aging is associated with a decline in various memory abilities, and sleep disturbances are also common. These processes involve the participation of numerous areas in the nervous system that interact with each other. Therefore, studying aging as a global process that can affect some centers more than others is a subject of great scientific and social interest. These studies at the neuronal network level could develop new therapies that may improve healthy aging. This work will focus on the changes that occur in neuronal circuits during aging which would explain the deterioration that occurs during normal aging in different cognitive processes such as learning, memory, attention or the sleep–wake cycle.

Prof. Dr. Ángel Núñez
Dr. Nuria García-Magro
Guest Editors

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Keywords

  • synaptic plasticity
  • neuronal excitability
  • intracellular signaling
  • glia
  • neuroinflammation
  • cognitive decline

Published Papers (1 paper)

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Review

14 pages, 897 KiB  
Review
Cognitive Deficits in Aging Related to Changes in Basal Forebrain Neuronal Activity
by Irene Chaves-Coira, Nuria García-Magro, Jonathan Zegarra-Valdivia, Ignacio Torres-Alemán and Ángel Núñez
Cells 2023, 12(11), 1477; https://doi.org/10.3390/cells12111477 - 25 May 2023
Cited by 4 | Viewed by 1818
Abstract
Aging is a physiological process accompanied by a decline in cognitive performance. The cholinergic neurons of the basal forebrain provide projections to the cortex that are directly engaged in many cognitive processes in mammals. In addition, basal forebrain neurons contribute to the generation [...] Read more.
Aging is a physiological process accompanied by a decline in cognitive performance. The cholinergic neurons of the basal forebrain provide projections to the cortex that are directly engaged in many cognitive processes in mammals. In addition, basal forebrain neurons contribute to the generation of different rhythms in the EEG along the sleep/wakefulness cycle. The aim of this review is to provide an overview of recent advances grouped around the changes in basal forebrain activity during healthy aging. Elucidating the underlying mechanisms of brain function and their decline is especially relevant in today’s society as an increasingly aged population faces higher risks of developing neurodegenerative diseases such as Alzheimer’s disease. The profound age-related cognitive deficits and neurodegenerative diseases associated with basal forebrain dysfunction highlight the importance of investigating the aging of this brain region. Full article
(This article belongs to the Special Issue Aging in Neuronal Networks)
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