JAK/STAT Signaling in Immunity and Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: closed (10 April 2022) | Viewed by 16196
Special Issue Editor
Interests: vascular endothelium; inflammation; haemostasis; cytokine signalling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Janus kinases (JAKs) comprise a family of receptor-bound tyrosine kinases essential for activation of signal transducer and activators of transcription (STATs) and other intracellular pathways downstream of type I and type II cytokine receptors. The significance of dysfunctional type I and type II cytokine receptor signaling in the pathogenesis of immune system disorders and specific cancers has made JAK-STAT signaling components attractive targets for the development of therapeutics for conditions such as rheumatoid arthritis, myeloproliferative neoplasms and alopecia areata. However, emerging mechanistic findings supports new approaches to target cytokine-activated JAK-STAT signaling, including novel strategies to modulate JAK activity, control of cytokine receptor dynamics and targeting endogenous feedback inhibitors.
This Special Issue aims to highlight the most recent advances on cytokine receptor control of JAK-STAT signaling and show how detailed understanding of mechanisms regulating cytokine receptor signaling and function is informing new therapeutic approaches for cancers and other diseases with strong immune and inflammatory components.
Prof. Timothy Martin Palmer
Guest Editor
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Keywords
- JAK-STAT
- type I and II cytokine receptors
- inflammation and immunity
- cancer
- signal transduction
- suppressors of cytokine signaling (SOCS)
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