Next Article in Journal
PXR Functionally Interacts with NF-κB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice
Previous Article in Journal
Associations between Pregnane X Receptor and Breast Cancer Growth and Progression
Open AccessReview

Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins

1
Molecular Oncology Laboratory, Cell Differentiation and Cancer Research Unit, FES Zaragoza, National University of Mexico, Batalla 5 de Mayo s/n Col. Ejército de Oriente, Mexico City 09230, Mexico
2
Cátedra CONACYT, CONACYT, Avenida Insurgentes Sur 1582, Col. Crédito Constructor Del. Benito Juárez, Mexico City 03940, Mexico
*
Author to whom correspondence should be addressed.
Cells 2020, 9(10), 2297; https://doi.org/10.3390/cells9102297
Received: 31 August 2020 / Revised: 11 October 2020 / Accepted: 12 October 2020 / Published: 15 October 2020
(This article belongs to the Special Issue JAK/STAT Signaling in Immunity and Disease)
The janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is associated with the regulation of essential cellular mechanisms, such as proliferation, invasion, survival, inflammation, and immunity. Aberrant JAK/STAT signaling contributes to cancer progression and metastatic development. STAT proteins play an essential role in the development of cervical cancer, and the inhibition of the JAK/STAT pathway may be essential for enhancing tumor cell death. Persistent activation of different STATs is present in a variety of cancers, including cervical cancer, and their overactivation may be associated with a poor prognosis and poor overall survival. The oncoproteins E6 and E7 play a critical role in the progression of cervical cancer and may mediate the activation of the JAK/STAT pathway. Inhibition of STAT proteins appears to show promise for establishing new targets in cancer treatment. The present review summarizes the knowledge about the participation of the different components of the JAK/STAT pathway and the participation of the human papillomavirus (HPV) associated with the process of cellular malignancy. View Full-Text
Keywords: signal transducer and activator of transcription; STAT inhibitors; signaling pathway; cervical cancer; HPV signal transducer and activator of transcription; STAT inhibitors; signaling pathway; cervical cancer; HPV
Show Figures

Figure 1

MDPI and ACS Style

Gutiérrez-Hoya, A.; Soto-Cruz, I. Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins. Cells 2020, 9, 2297.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop