Immune Mechanisms in Glomerulonephritis
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: closed (20 October 2022) | Viewed by 26828
Special Issue Editor
Special Issue Information
Dear Colleagues,
Components of the innate and adaptive immune system critically mediate, but also regulate inflammation in different forms of glomerulonephritis. We do need this information to develop new therapeutic strategies to fight disease since current immunosuppressive protocol are still associated with serious short and long-term side effects such as infection, cancer and diabetes which all together increase mortality in this patient population. Recent clinical trials have shown efficacy of B-cell depleting strategies and complement inhibition in ANCA vasculitis, which would not have been possible without a fundamental understanding of immune mechanisms in this disease entity. In contrast, various immunosuppressive strategies failed in IgA nephropathy, whereas encapsuled budesonide acting locally in the terminal ileum as well as SGLT-2 inhibition improved the outcome. Still, pathomechanisms responsible for these protective effects are largely unknown.
The primary focus of this of this topic will be reviews and research articles, which explore immune mechanisms in various glomerulonephritis entities and current as well as novel immune-modulating/inhibiting strategies in the treatment of glomerulonephritis.
Dr. Kathrin Eller
Guest Editor
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Keywords
- glomerulonephritis
- complement
- T cells
- B cells
- Innate immune cells
- Chemokines
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