Metabolic Remodeling in Heart Failure: Cause or Consequence?
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Cardiovascular System".
Deadline for manuscript submissions: closed (1 December 2022) | Viewed by 3262
Special Issue Editors
Interests: molecular cardiology; mitochondrial biology; transcriptional regulation.
Special Issue Information
Dear Colleagues,
We are pleased to invite you to submit your work to this Special Issue of Cells on metabolic remodeling in heart failure.
There is no doubt that heart function is closely associated with metabolism at both the myocardial and systemic levels. Despite its high-energy demand, the heart contains relatively low ATP reserves, and thus, a strict control of myocardial metabolism is a requisite to ensure a continual supply of energy. Not surprisingly, heart failure is highly associated with energy insufficiency and metabolic remodeling in the myocardium. Conversely, heart failure causes reduced blood perfusion to the body that may alter peripheral metabolism due to tissue hypoxia, acidification, electrolyte disturbances or substrate deprivation. Finally, abnormalities in whole-body metabolism, such as hyperglycemia and hyperlipidemia, are well-known risk factors of heart failure.
However, many issues still remain debatable. For example, is metabolic remodeling a cause or consequence of heart failure, or an interplay of the two sides? What is the precise cause of myocardial metabolic dysfunction in the non-ischemic settings and in the chronic remodeling phase post-MI? What are the molecular mechanisms underlying metabolic remodeling in the myocardium of chronic heart failure? As heart failure is largely a disease of the elderly, how does aging affect or remodel metabolism? How can we improve heart failure treatments by targeting the metabolic pathways? This Special Issue aims to discuss the above questions and other related topics.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: animal heart failure studies (with focus on metabolism), molecular and pathological studies of clinic heart failure, cellular metabolism, mitochondrial biology, autophagy/mitophagy, translational studies on targeting metabolism in heart failure, etc.
We look forward to receiving your contributions.
Dr. Xudong Liao
Dr. Ippei Watanabe
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- heart failure
- cardiomyopathy
- metabolism
- remodeling
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
