Lipids and Lipidomics in Neurodegenerative Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Neuroscience".
Deadline for manuscript submissions: closed (20 November 2025) | Viewed by 21636
Special Issue Editors
Interests: health; chronic diseases; metabolism; lipids; inflammation; oxidative stress; bioengineering
Special Issues, Collections and Topics in MDPI journals
Interests: brain aging; Alzheimer’s disease; neurodegenerative diseases; neuronal membranes; lipids; nutrition; membrane protein interactions; endocytosis; vesicular trafficking; biomarkers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurodegenerative diseases represent one of the major health emergencies and one of the leading causes of death worldwide. Millions of individuals are impacted by neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, or amyotrophic lateral sclerosis. Multiple pathological processes contribute to the progression of these diseases, including neuroinflammation, oxidative stress, endoplasmic reticulum stress, and neuronal death, although the precise causes and chronology of these events have not yet been established. It is nevertheless accepted that the disruption of lipid homeostasis contributes greatly to the pathogenesis of neurodegenerative diseases, particularly due to the high lipid content of brain tissue. Lipids are active biomolecules that play key roles in various cerebral cellular processes, such as neuronal membrane dynamics, interactions with membrane proteins, and the consequences for their functionality, signaling and gene regulation, and endo/exocytosis. Understanding their role in the development of neurodegenerative diseases is therefore essential and must be based on relevant fundamental research. In this context, lipidomics represents a major research tool for understanding the mechanisms, discovering prognostic or diagnostic biomarkers, and identifying therapeutic targets, given the wide diversity of lipid molecular species involved.
To date, the treatment and cure of neurodegenerative disease remain a significant challenge because of an incomplete understanding of the events that lead to the selective neurodegeneration of brains. The aim of this Special Issue is to provide an overview of the current knowledge of molecular and cellular lipid pathways involved in neurodegenerative diseases, lipid alterations associated with neurodegenerative diseases, the interest of lipids in the treatment of neurodegenerative diseases, and lipidomics in the prevention, diagnosis, and treatment of neurodegenerative diseases.
This Special Issue welcomes submissions of original studies and reviews.
Dr. Nathalie Bernoud-Hubac
Dr. Catherine Malaplate
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- lipids
- lipidomics
- neurodegenerative disease diagnosis, prevention, or treatment
- cellular and molecular mechanisms
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
