Special Issue "Highlights of the 3rd Meeting of the French Society for Stem Cell Research (FSSCR)"

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".

Deadline for manuscript submissions: 29 February 2020.

Special Issue Editors

Dr. Pierre Savatier
E-Mail Website
Guest Editor
INSERM U1208, Stem Cell and Brain Research Institute, 18 avenue Doyen Lepine, 69500 Bron, France
Interests: pluripotent stem cells; embryo chimeras; cycle regulation
Dr. Cécile Martinat
E-Mail Website
Guest Editor
INSERM UEVE UMR 861, I-STEM, Association Française des Myopathies, 28 Rue Henri Desbruères, 91100 Corbeil Essonnes
Interests: human pluripotent stem cells,differentiation, disease modeling, drug screening, cell therapy
Dr. Thierry Jaffredo
E-Mail Website
Guest Editor
Institut de Biologie Paris Seine, CNRS UMR7622, INSERM U1156, Sorbonne Université, 9 Quai St Bernard, 75252 Paris Cedex 05, France
Interests: development; stem cells; hematopoietic stem cells; niche cells; stem cell niche interactions; high troughput approaches

Special Issue Information

Dear Colleagues,

The 3rd annual meeting of the French Society for Stem Cell Research (FSSCR) will be held in Lyon on November 18 and 19, 2019. It will be organized around four sessions: “Gastruloids and Blastoids”, “Organoids”, “Stem Cells at the Single Cell Level”, and “Epigenetics and Aging”. All participants wishing to submit an Abstract at any of these four sessions, whether for a poster or a short presentation, have the opportunity to also submit an article for publication in this Special Issue of Cells. This article can be a review or an original manuscript.

Dr. Thierry Jaffredo
Dr. Pierre Savatier
Dr. Cécile Martinat
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

Open AccessArticle
NOTO Transcription Factor Directs Human Induced Pluripotent Stem Cell-Derived Mesendoderm Progenitors to a Notochordal Fate
Cells 2020, 9(2), 509; https://doi.org/10.3390/cells9020509 (registering DOI) - 24 Feb 2020
Abstract
The founder cells of the Nucleus pulposus, the centre of the intervertebral disc, originate in the embryonic notochord. After birth, mature notochordal cells (NC) are identified as key regulators of disc homeostasis. Better understanding of their biology has great potential in delaying the [...] Read more.
The founder cells of the Nucleus pulposus, the centre of the intervertebral disc, originate in the embryonic notochord. After birth, mature notochordal cells (NC) are identified as key regulators of disc homeostasis. Better understanding of their biology has great potential in delaying the onset of disc degeneration or as a regenerative-cell source for disc repair. Using human pluripotent stem cells, we developed a two-step method to generate a stable NC-like population with a distinct molecular signature. Time-course analysis of lineage-specific markers shows that WNT pathway activation and transfection of the notochord-related transcription factor NOTO are sufficient to induce high levels of mesendoderm progenitors and favour their commitment toward the notochordal lineage instead of paraxial and lateral mesodermal or endodermal lineages. This study results in the identification of NOTO-regulated genes including some that are found expressed in human healthy disc tissue and highlights NOTO function in coordinating the gene network to human notochord differentiation. Full article
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