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Networks and Hubs Re-defining the Role of the Connectome in...
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Networks and Hubs Re-defining the Role of the Connectome in the Nervous System

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1938

Special Issue Editors

Dr. Ciro De Luca

E-Mail Website
Guest Editor
Laboratory of Neuronal Networks Morphology and Systems Biology, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Interests: neurology; neuroanatomy; clinical neurophysiology; migraine; synaptic plasticity models; glial cells
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Michele Papa

E-Mail Website1 Website2
Guest Editor
Laboratory of Neuronal Networks Morphology and System Biology, Department of Mental and Physical Health and Preventive Medicine, University of Campania ‘‘Luigi Vanvitelli”, 80138 Naples, Italy
Interests: neuroinflammation; astrocytes; synaptic plasticity; nerve growth factor; vagus nerve stimulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue offers the opportunity for an open and peer-reviewed debate about modern theories and experiments identifying the shape of the nervous system connectome. The fine structure and defined connections of neuronal networks hardly prove to be necessary and sufficient in explaining the emergent properties of the system. From bench to bedside, evidence has been accumulated for the definition of novel theories that look at epigenetic, transcriptional, and protein-based mechanisms that could change the neural network paradigms.

Here, we accept novel ideas and research regarding the nervous system connectome through pathological and physiological models. Different approaches will be accepted as long as the novelty of the proposed theory and experimental settings is well elucidated.

Dr. Ciro De Luca
Prof. Dr. Michele Papa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • connectome
  • CNS
  • omics
  • systems biology
  • connectome
  • CNS pathology

Published Papers (1 paper)

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Review

19 pages, 1045 KiB  
Review
Shared Molecular Pathways in Glaucoma and Other Neurodegenerative Diseases: Insights from RNA-Seq Analysis and miRNA Regulation for Promising Therapeutic Avenues
by Carlos Franciney Moreira Vasconcelos, Vinicius Toledo Ribas and Hilda Petrs-Silva
Cells 2023, 12(17), 2155; https://doi.org/10.3390/cells12172155 - 28 Aug 2023
Viewed by 1763
Abstract
Advances in RNA-sequencing technologies have led to the identification of molecular biomarkers for several diseases, including neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, Huntington’s diseases and Amyotrophic Lateral Sclerosis. Despite the nature of glaucoma as a neurodegenerative disorder with several similarities with the other [...] Read more.
Advances in RNA-sequencing technologies have led to the identification of molecular biomarkers for several diseases, including neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, Huntington’s diseases and Amyotrophic Lateral Sclerosis. Despite the nature of glaucoma as a neurodegenerative disorder with several similarities with the other above-mentioned diseases, transcriptional data about this disease are still scarce. microRNAs are small molecules (~17–25 nucleotides) that have been found to be specifically expressed in the CNS as major components of the system regulating the development signatures of neurodegenerative diseases and the homeostasis of the brain. In this review, we sought to identify similarities between the functional mechanisms and the activated pathways of the most common neurodegenerative diseases, as well as to discuss how those mechanisms are regulated by miRNAs, using RNA-Seq as an approach to compare them. We also discuss therapeutically suitable applications for these disease hallmarks in clinical future studies. Full article
(This article belongs to the Special Issue Networks and Hubs Re-defining the Role of the Connectome in the Nervous System)
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