Cyclic AMP/PKA/Epac Signaling in Health and Disease

Dear Colleagues,

Cellular signaling associated with cAMP (cyclic AMP) and its target proteins PKA (protein kinase A) and Epac (guanine nucleotide exchange protein directly activated by cAMP) is important in regulating the function of various cell types including those in the cardiovascular, respiratory, excretory, brain, and other systems. The key issues related to cAMP signaling particularly in disease and prevention, remain unanswered or not fully understood.  For example, the interaction between PKA and Epac pathways and their interplay with calcium regulation, oxidative stress, and the mitochondria. A major advance in this area has been the availability of cell-permeable cAMP analogues, which have been used to elucidate relevant cellular activities and to demonstrate protection against pathologies. Nonetheless, more work is needed to understand the exact role PKA and different Epac isoforms as well as their expression/cellular distribution in different cell types.

This Special Issue aims to update the current knowledge on the role of cAMP/PKA/Epac signaling in different cell types and to integrate this information to better understand its role in health and disease. This could be related to virtually any pathological condition in different cells, organs, and systems. It is anticipated that such knowledge will help in formulating novel therapeutic interventions that target this signaling pathway.

We look forward to your contributions.

Prof. Dr. M.-Saadeh Suleiman
Dr. Igor Khaliulin
Guest Editors

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