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Special Issue "Regulation of Apoptosis by the Bcl-2 Family of Proteins"
Deadline for manuscript submissions: 31 January 2020.
Interests: protein–membrane interactions; Bcl-2 proteins; regulation of apoptosis; conformational switching; cancer
Special Issues and Collections in MDPI journals
The critical step in triggering apoptosis is the permeabilization of the mitochondrial outer membrane (MOMP), which is controlled and executed by the numerous proteins of Bcl-2 family. In spite of the recent advances in solving the structures of the soluble conformations, the exact mechanism of Bcl-2 proteins remains unresolved, primarily because the functionally-important conformations are induced by interactions with the membrane. A major knowledge gap is the lack of accurate molecular pictures of protein–protein and protein–lipid interactions mediating MOMP. This Special Issue seeks reviews and original papers, both experimental and computational, covering a wide range of topics related to structure–function relationships of Bcl-2 proteins, their role in various disorders and their potentials as therapeutic targets.
Prof. Alexey S. Ladokhin
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- mitochondrial outer membrane permeabilization
- protein-membrane interactions
- Bcl-2 proteins as therapeutic targets