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The Incomplete Puzzle of the BCL2 Proteins

Interfaculty Institute of Biochemistry, Eberhard-Karls-Universität Tübingen, 72076 Tübingen, Germany
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Cells 2019, 8(10), 1176; https://doi.org/10.3390/cells8101176
Received: 3 September 2019 / Revised: 25 September 2019 / Accepted: 26 September 2019 / Published: 29 September 2019
(This article belongs to the Special Issue Regulation of Apoptosis by the Bcl-2 Family of Proteins)
The proteins of the BCL2 family are key players in multiple cellular processes, chief amongst them being the regulation of mitochondrial integrity and apoptotic cell death. These proteins establish an intricate interaction network that expands both the cytosol and the surface of organelles to dictate the cell fate. The complexity and unpredictability of the BCL2 interactome resides in the large number of family members and of interaction surfaces, as well as on their different behaviours in solution and in the membrane. Although our current structural knowledge of the BCL2 proteins has been proven therapeutically relevant, the precise structure of membrane-bound complexes and the regulatory effect that membrane lipids exert over these proteins remain key questions in the field. Here, we discuss the complexity of BCL2 interactome, the new insights, and the black matter in the field. View Full-Text
Keywords: BCL2 proteins; MOMP; protein membrane interactions; apoptosis; cancer therapy BCL2 proteins; MOMP; protein membrane interactions; apoptosis; cancer therapy
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Flores-Romero, H.; García-Sáez, A.J. The Incomplete Puzzle of the BCL2 Proteins. Cells 2019, 8, 1176.

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