Neurogenesis and Regeneration in Teleost Central Nervous System

Dear Colleagues,

In our modern society, neurodegenerative diseases, along with cancer, pose one of the main health threats, as the number of older citizens is rising. These diseases are characterized by a progressive degeneration of neurons, which eventually leads to their death and to the disintegration of the nervous system structure.

Currently, neurodegenerative diseases are incurable, as the available treatments either only manage the symptoms or slow down disease progression.

Deciphering the cellular and molecular mechanisms of adult neurogenesis and regeneration is of great importance because it will eventually allow us to identify specific reactive neurogenesis mechanisms and re-instruct neurogenesis in patients suffering from neurodegenerative conditions.

Lately, zebrafish has become a popular model in biomedical research due to its experimental advantages, the existence of numerous genetic manipulation tools and various genetic resources, and the fact that the genetic basis of most diseases is shared between human and zebrafish.

The present Special Issue aims to summarize some of the latest advances in the field of adult neurogenesis and regeneration, using zebrafish as a model organism. We intend to highlight the key molecular mechanisms involved in neurogenesis, under normal physiological conditions and regenerative conditions, in the zebrafish nervous system, focusing on different regions of the brain, retina, and spinal cord.

Dr. Sepand Rastegar
Dr. Luisa Lübke
Guest Editors

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