Advances in Melanoma Immunotherapy

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 3008

Special Issue Editor


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Guest Editor
College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Interests: dermatopathology

Special Issue Information

Dear Colleagues,

The field of melanoma treatment is witnessing revolutionary advancements, particularly in the field of immunotherapy. This special issue aims to encapsulate these groundbreaking changes by gathering cutting-edge research focused on the mechanisms, efficacy, and future directions of immunotherapies and other new therapies against metastatic melanoma. We invite contributions that explore novel therapeutic targets and immune response modulation. Our goal is to provide a comprehensive overview that will inform and inspire ongoing and future efforts in combating melanoma through immunological approaches.

Dr. Jeffrey D. McBride
Guest Editor

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Keywords

  • melanoma immunotherapy
  • therapeutic targets
  • immune modulation
  • oncolytic viruses
  • checkpoint inhibitors
  • cancer vaccines
  • tumor biomarkers
  • tumor microenvironment
  • treatment strategies

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Published Papers (1 paper)

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Review

18 pages, 1531 KiB  
Review
The Utilization of PRAME in the Diagnosis, Prognosis, and Treatment of Melanoma
by Samuel L. Blount, Xiaochen Liu and Jeffrey D. McBride
Cells 2024, 13(20), 1740; https://doi.org/10.3390/cells13201740 - 20 Oct 2024
Viewed by 2503
Abstract
Melanoma, a deadly form of skin cancer, has seen improved survival rates due to advances in diagnosis and treatment, yet the need for further improvement remains critical. Tumor-associated antigens, such as PRAME (Preferentially Expressed Antigen in Melanoma), offer promising avenues for enhanced diagnostic [...] Read more.
Melanoma, a deadly form of skin cancer, has seen improved survival rates due to advances in diagnosis and treatment, yet the need for further improvement remains critical. Tumor-associated antigens, such as PRAME (Preferentially Expressed Antigen in Melanoma), offer promising avenues for enhanced diagnostic precision, prognostic assessment, and targeted immunotherapy. PRAME, a cancer testis antigen, is selectively expressed in various cancers, including melanoma, and plays a key role in promoting tumorigenesis through inhibition of retinoic acid signaling, epithelial-to-mesenchymal transition, and immune evasion. This review explores the diagnostic utility of PRAME in distinguishing melanoma from benign nevi, its prognostic value in aggressive melanoma subtypes, and its potential as a therapeutic target in cancer vaccines and adoptive T-cell therapies. While PRAME-targeted therapies face challenges such as tumor heterogeneity and immune suppression, ongoing research aims to overcome these barriers, offering hope for more effective melanoma treatments. Full article
(This article belongs to the Special Issue Advances in Melanoma Immunotherapy)
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