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Cells
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Sebaceous Gland in Skin Health and Disease
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Sebaceous Gland in Skin Health and Disease

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 1045

Special Issue Editors

Dr. Stefania Briganti

E-Mail Website
Guest Editor
Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatological Institute, IRCCS, 00144 Rome, Italy
Interests: skin lipids; sebocytes; keratinocytes; melanocytes; sebum; stratum corneum; skin cancer; inflammatory skin diseases; mass spectrometry; lipidomics; metabolomics
Dr. Monica Ottaviani

E-Mail Website
Guest Editor
Laboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatological Institute, IRCCS, 00144 Rome, Italy
Interests: skin lipids; sebocytes; keratinocytes; melanocytes; sebum; stratum corneum; skin cancer; inflammatory skin diseases; mass spectrometry; lipidomics; metabolomics

Special Issue Information

Dear Colleagues,

The sebaceous gland (SG) has long been regarded as a living fossil in the skin, and its activity has, therefore, been underestimated. Over time, however, the discovery of the multitude of receptors expressed by sebocytes has widened our understanding of the SG’s activities. In addition to the skin protection function that it performs through sebum production and excretion, the SG has metabolic, neuroendocrine, and immunological functions, revealing the key role of the SG in skin health and integrity, as well as in skin diseases. The knowledge acquired so far has meant that further exploration and understanding of the SG have become the focus of scientific discussions in dermatology.

This Special Issue will examine the SG’s participation in skin homeostasis, inflammatory processes, and pathophysiological mechanisms; the factors affecting sebocyte function; the sebaceous lipid alterations involved in skin disorders; the pathological or therapeutic implication of SG activity and sebum composition changes; and the identification of possible SG-related biomarkers useful in the prevention, diagnosis, and treatment of inflammatory skin diseases.

Dr. Stefania Briganti
Dr. Monica Ottaviani
Guest Editors

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Keywords

  • sebaceous gland
  • sebocytes
  • sebaceous lipid
  • sebum
  • inflammation
  • sebaceous gland disease
  • skin diseases
  • pathophysiology
  • biomarkers
  • therapeutics

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Published Papers (2 papers)

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18 pages, 7081 KiB  
Article
A Potential Role for c-MYC in the Regulation of Meibocyte Cell Stress
by Isabella Boyack, Autumn Berlied and Cornelia Peterson
Cells 2025, 14(10), 709; https://doi.org/10.3390/cells14100709 - 14 May 2025
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Abstract
The integrated stress response (ISR) is a key regulator of cell survival, promoting apoptosis through the effector protein CHOP in instances of prolonged or severe stress. The ISR’s role in the initiation and progression of epithelial malignancies has been investigated; however, the ISR [...] Read more.
The integrated stress response (ISR) is a key regulator of cell survival, promoting apoptosis through the effector protein CHOP in instances of prolonged or severe stress. The ISR’s role in the initiation and progression of epithelial malignancies has been investigated; however, the ISR has not been evaluated in ocular adnexal sebaceous carcinoma (SebCA). Though uncommon, mortality rates of up to 40% have been reported, and the mechanisms underlying SebCA tumorigenesis remain unresolved; however, c-MYC upregulation has been documented. Our objective was to determine the role of MYC in modulating the ISR in the Meibomian gland. Human Meibomian gland epithelial cells (HMGECs) were subject to both pharmacologic and genetic manipulations of MYC expression. Cytotoxicity, proliferation, and changes in protein and gene expression were assessed. Conditionally MYC-overexpressing mice were subject to topical 4-hydroxytamoxifen (4-OHT) induction of the eyelids prior to tissue harvest for histology, immunohistochemistry, immunoblotting, and qPCR. MYC-inhibited HMGECs exhibited dose-dependent decreased proliferation, increased CHOP expression, and increased apoptosis. Conversely, MYC-overexpressing HMGECs and Meibomian glands from 4-OHT-induced mice demonstrated suppressed CHOP expression, reduced apoptosis, and upregulated fatty acid synthase expression. These results suggest that MYC inhibition induces the ISR and promotes apoptosis, while MYC induction suppresses CHOP expression. High MYC expression may, therefore, serve as a mechanism for SebCA to elude cell death by promoting lipogenesis. Full article
(This article belongs to the Special Issue Sebaceous Gland in Skin Health and Disease)
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Review

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28 pages, 1535 KiB  
Review
The Sebaceous Gland: A Key Player in the Balance Between Homeostasis and Inflammatory Skin Diseases
by Sarah Mosca, Monica Ottaviani, Stefania Briganti, Anna Di Nardo and Enrica Flori
Cells 2025, 14(10), 747; https://doi.org/10.3390/cells14100747 - 20 May 2025
Viewed by 76
Abstract
The sebaceous gland (SG) is an integral part of the pilosebaceous unit and is a very active and dynamic organ that contributes significantly to the maintenance of skin homeostasis. In addition to its primary role in sebum production, the SG is involved in [...] Read more.
The sebaceous gland (SG) is an integral part of the pilosebaceous unit and is a very active and dynamic organ that contributes significantly to the maintenance of skin homeostasis. In addition to its primary role in sebum production, the SG is involved in the maintenance of skin barrier function, local endocrine/neuroendocrine function, the innate immune response, and the regulation of skin bacterial colonization. Structural and functional alterations of SGs leading to the dysregulation of sebum production/composition and immune response may contribute to the pathogenesis of inflammatory dermatoses. This review summarises the current knowledge on the contribution of SGs to the pathogenesis of common inflammatory skin diseases. These findings are crucial for the development of more effective therapeutic strategies for the treatment of inflammatory dermatoses. Full article
(This article belongs to the Special Issue Sebaceous Gland in Skin Health and Disease)
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