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Cells
Volume 14
Issue 10
10.3390/cells14100747
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Review

The Sebaceous Gland: A Key Player in the Balance Between Homeostasis and Inflammatory Skin Diseases

by
Sarah Mosca
,
Monica Ottaviani
*,
Stefania Briganti
*,
Anna Di Nardo
and
Enrica Flori
Laboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatological Institute, IRCCS, 00144 Rome, Italy
*
Authors to whom correspondence should be addressed.
Cells 2025, 14(10), 747; https://doi.org/10.3390/cells14100747
Submission received: 14 April 2025 / Revised: 16 May 2025 / Accepted: 19 May 2025 / Published: 20 May 2025
(This article belongs to the Special Issue Sebaceous Gland in Skin Health and Disease)
Versions Notes

Abstract

The sebaceous gland (SG) is an integral part of the pilosebaceous unit and is a very active and dynamic organ that contributes significantly to the maintenance of skin homeostasis. In addition to its primary role in sebum production, the SG is involved in the maintenance of skin barrier function, local endocrine/neuroendocrine function, the innate immune response, and the regulation of skin bacterial colonization. Structural and functional alterations of SGs leading to the dysregulation of sebum production/composition and immune response may contribute to the pathogenesis of inflammatory dermatoses. This review summarises the current knowledge on the contribution of SGs to the pathogenesis of common inflammatory skin diseases. These findings are crucial for the development of more effective therapeutic strategies for the treatment of inflammatory dermatoses.
Keywords: sebaceous gland; sebocyte; inflammatory skin disorders; acne; hidradenitis suppurativa; rosacea; seborrheic dermatitis; atopic dermatitis; psoriasis; eosinophilic pustular folliculitis; melasma sebaceous gland; sebocyte; inflammatory skin disorders; acne; hidradenitis suppurativa; rosacea; seborrheic dermatitis; atopic dermatitis; psoriasis; eosinophilic pustular folliculitis; melasma

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MDPI and ACS Style

Mosca, S.; Ottaviani, M.; Briganti, S.; Di Nardo, A.; Flori, E. The Sebaceous Gland: A Key Player in the Balance Between Homeostasis and Inflammatory Skin Diseases. Cells 2025, 14, 747. https://doi.org/10.3390/cells14100747

AMA Style

Mosca S, Ottaviani M, Briganti S, Di Nardo A, Flori E. The Sebaceous Gland: A Key Player in the Balance Between Homeostasis and Inflammatory Skin Diseases. Cells. 2025; 14(10):747. https://doi.org/10.3390/cells14100747

Chicago/Turabian Style

Mosca, Sarah, Monica Ottaviani, Stefania Briganti, Anna Di Nardo, and Enrica Flori. 2025. "The Sebaceous Gland: A Key Player in the Balance Between Homeostasis and Inflammatory Skin Diseases" Cells 14, no. 10: 747. https://doi.org/10.3390/cells14100747

APA Style

Mosca, S., Ottaviani, M., Briganti, S., Di Nardo, A., & Flori, E. (2025). The Sebaceous Gland: A Key Player in the Balance Between Homeostasis and Inflammatory Skin Diseases. Cells, 14(10), 747. https://doi.org/10.3390/cells14100747

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