Mechanistic Insights into Nanomaterial-Induced Immunotoxicity: Exploring Pathways of Immune Dysregulation
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: 10 June 2025 | Viewed by 150
Special Issue Editor
Interests: gut-liver-brain axis; microbiota; metagenomics; stress; ionization radiation; fetal alcohol
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue aims to uncover how nanomaterials affect immune system function at cellular and molecular levels, investigating interactions between nanomaterials (e.g., metal nanoparticles, carbon nanotubes, and polymeric nanostructures) and key immune cells, such as macrophages, dendritic cells, T cells, and B cells. This Special Issue will focus on inflammatory pathways, including the activation of pattern recognition receptors (e.g., Toll-like receptors) and inflammasomes like NLRP3, which can drive immune responses. Additionally, the potential for nanomaterials to induce hyperinflammatory states, such as cytokine storms, or suppress immune function by impairing antigen presentation and cytokine production will be evaluated. The Special Issue will also explore how properties like size, shape, surface charge, and functionalization influence immunotoxicity. Long-term effects, including chronic inflammation and fibrosis resulting from nanomaterial biopersistence, will be assessed. The Special Issue will utilize in vitro immune models, in vivo animal studies, and advanced tools like transcriptomics, proteomics, and cytokine profiling to map immune responses. Real-time imaging methods, such as multiphoton microscopy, will provide insights into nanomaterial–immune interactions. This Special Issue aims to inform the design of safer nanomaterials and reduce risks in biomedical, environmental, and industrial applications.
Dr. Pradeep K. Shukla
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- nanomaterials
- immune cells
- macrophages
- inflammasomes
- immunotoxicity
- immune responses
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
