Cellular Mechanisms in Mitochondrial Function and Calcium Signaling

Dear Colleagues,

Calcium (Ca²⁺) is a ubiquitous second messenger whose signaling is regulated by compartmentalization and transport across several cellular membranes. Ca²⁺ controls a wide range of cellular processes, from cellular contraction to exocytosis or gene expression. Mitochondria transform the free energy stored in highly reduced compounds into chemical energy in the form of ATP to support energy-consuming cellular processes across the cell. Beyond this well-known role, mitochondria are crucial in apoptosis, metabolite biosynthesis, and cellular immune response, among other cellular processes. Mitochondrial function is highly integrated within the specific cellular context of each cell, and Ca²⁺ signals play a key role in maintaining it. The functional interaction between cellular Ca²⁺ signaling and mitochondria is complex; mitochondria can contribute to trigger and shape cytosolic Ca²⁺ signals while also sensing, decoding, and responding to such Ca²⁺ signals. Moreover, they frequently also involve other organelles such as the plasma membrane or the endoplasmic/sarcoplasmic reticulum. This Special Issue aims to publish manuscripts that explore the intricate relationships between mitochondria and cellular calcium homeostasis in both health and disease.

Dr. Sergio De la Fuente
Dr. Jaime Santo-Domingo
Guest Editors

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