Cellular Mechanisms in Mitochondrial Function and Calcium Signaling
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Metabolism".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 1689
Special Issue Editors
Interests: mitochondria; Ca2+; aging; heart; organelle contactology; bioenergetics
Special Issue Information
Dear Colleagues,
Calcium (Ca2+) is a ubiquitous second messenger whose signaling is regulated by compartmentalization and transport across several cellular membranes. Ca2+ controls a wide range of cellular processes, from cellular contraction to exocytosis or gene expression. Mitochondria transform the free energy stored in highly reduced compounds into chemical energy in the form of ATP to support energy-consuming cellular processes across the cell. Beyond this well-known role, mitochondria are crucial in apoptosis, metabolite biosynthesis, and cellular immune response, among other cellular processes. Mitochondrial function is highly integrated within the specific cellular context of each cell, and Ca2+ signals play a key role in maintaining it. The functional interaction between cellular Ca2+ signaling and mitochondria is complex; mitochondria can contribute to trigger and shape cytosolic Ca2+ signals while also sensing, decoding, and responding to such Ca2+ signals. Moreover, they frequently also involve other organelles such as the plasma membrane or the endoplasmic/sarcoplasmic reticulum. This Special Issue aims to publish manuscripts that explore the intricate relationships between mitochondria and cellular calcium homeostasis in both health and disease.
Dr. Sergio De la Fuente
Dr. Jaime Santo-Domingo
Guest Editors
Manuscript Submission Information
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Keywords
- mitochondria
- calcium
- MCU
- uniporter
- NCLX
- energy metabolism
- disease
- MAMs
- signaling
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