Molecular Biology of Haemorrhagic Shock
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (14 December 2021) | Viewed by 480
Special Issue Editors
Pittsburgh Trauma Research Center, Division of Trauma and Acute Care Surgery, University of Pittsburgh, 24 Pittsburgh, PE, USA
Interests: hemorrhagic shock; Post-traumatic sepsis; shock; trauma; sepsis
Pittsburgh Trauma Research Center, Division of Trauma and Acute Care Surgery, University of Pittsburgh, 24 Pittsburgh, PE, USA
Interests: trauma immunology; molecular diagnostics & biomarkers; drug development
Special Issue Information
Dear Colleagues,
The majority of potentially preventable deaths after trauma are related to haemorrhagic shock (HS), which occurs early after injury. Haemorrhagic shock (HS) is the outcome of many etiologic factors. The molecular mechanisms underlying the development and progression of HS are still under active investigation. Among the complex signalling networks that characterizes HS are imbalance between innate and adaptive immune response, dysfunction, cytokine upregulation, inflammation, alteration of extracellular matrix homeostasis, fibrosis, defective autophagy and apoptosis, metabolic abnormalities, and mitochondrial dysfunction. to name only a few. In recent years, due to technological progress, systems biology approaches have been applied to mechanistically explaining the different underlying etiologic factors of HS. This Special Issue titled “Molecular Biology of Haemorrhagic Shock” highlights the ongoing challenges in the field and research being undertaken to more thoroughly understand the underlying molecular mechanisms. Curated by Dr. Billiar, the Special Issue contains a selection of articles and commissioned content from leading researchers in the field to present a broad-scope view of current research focal points and to explore future directions of therapy design, stratification, and patient management.
Prof. Timothy R. Billiar
Dr. Upendra K. Kar
Guest Editors
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Keywords
- haemorrhagic shock (HS)
- traumatic injury
- resuscitation
- blood transfusion
- reperfusion injury
- Inflammation
- Immune response
- gene regulation
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