Uncovering the Effects of Synthetic Substances on Cellular Processes: From Food Additives and Drugs to Nanoparticles and Microplastics

Dear Colleagues,

The production and use of synthetic materials have increased dramatically in recent years, raising concerns about their impact on both human health and the environment. Most of these substances do not degrade naturally, but instead accumulate in living organisms due to their chemical stability and resistance to biodegradation. Furthermore, the accumulation of synthetic materials in the environment can have harmful effects on ecosystems, including food chains disruption and wildlife violation. While many substances ranging from food additives and medications to microplastics and nanoparticles have been extensively tested for safety, there is still much unknown about their short-term and long-term effects, particularly about their interaction with living organisms.

In this special issue, we aim to explore the effects of different synthetic substances on various physiological and toxicological parameters, oxidative stress markers, signaling molecules, and cellular signaling pathways, as well as cellular processes, including cell proliferation, differentiation, and death. Through the exploration of these aspects, this special issue aims to contribute to a better understanding the synthetic substances’ mechanisms of action, and to support the development of strategies to mitigate their potential risks for living beings and the environment.

Dr. Sanja Stankovic
Dr. Snežana A. Pejić
Dr. Dunja Drakulić
Dr. Ana Todorović
Guest Editors

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