Type 1 Diabetes and Associated Immune-Mediated Diseases: Focus on Environmental Factors
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Metabolism".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2972
Special Issue Editors
Interests: immunology; diabetes; microbiota; metabolites; associated immune-mediated diseases
Interests: Type 1 diabetes; celiac disease; intestinal permeability; Enterovirus; Gluten-Free Diet; Innate immune system; Beta cell; beta-cell stress; islet of Langerhans; NOD mouse
Special Issue Information
Dear Colleagues,
Type 1 diabetes (T1D) is an autoimmune disease in which environmental factors play an important role, as documented by the remarkably growing T1D incidence in developed countries and decreasing age of disease onset in recent decades. Pathogenic, effector, and regulatory immune responses may all be influenced by the environment, but due to their complexities and variability, these interactions are difficult to dissect and to define, yet they represent a promising and relatively safe approach in disease prevention or arrest. Infections, dietary factor, intestinal microbiota, metabolism and metabolites, and their interplays are capable of shaping preferentially mucosal, adaptive and innate immune responses.
The aim of this Special Issue is thus to focus attention on the immune mechanisms as well as interplays with environmental factors in T1D. This is, however, also relevant in many other immune-mediated diseases with different genetic predispositions and initial etiopathogenic hits. Therefore, the focus of this Special Issue is on the role of immunity, diets, microbiota, and/or metabolites not confined only to T1D, but also including T1D-associated autoimmune diseases such as celiac disease, autoimmune thyroid disease, autoimmune gastritis, pernicious anemia, Sjogren's syndrome, as well as other immune-mediated diseases (e.g., psoriasis or Parkinson's disease) in which parallels in terms of the role of immunity and the environment may be found.
In this Special Issue, we invite scientists to contribute all article types published in Cells and within the framework of the above-described aims.
Dr. David Funda
Dr. Martin Haupt-Jorgensen
Guest Editors
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Keywords
- type 1 diabetes
- immune mechanisms
- environmental factors
- infection
- diets
- microbiota
- metabolites
- associated immune-mediated diseases
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