Genetic, Epigenetic, and Transcriptional Control of Cancer Stem Cell
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".
Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 4297
Special Issue Editors
Interests: cancer stem cell; cancer microenvironment; hypoxia; pluripotency factor; epigenetics; targeted therapy
Interests: epigenetics; DNA damage and repair; target therapy; immunotherapy
Interests: gene transcription; tumor microenvironment; hypoxia; HIFs; epigenetics; cancer stem cell; immunotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Tumor heterogeneity is a key characteristic of cancer. Cancer stem cells are a small population of cancer cells that have infinite proliferative potential and tumor-initiating properties. Cancer stem cells play a critical role in the initiation, recurrence/metastasis and therapeutic resistance of cancer. Therefore, a deeper understanding of cancer stem cell is urgently needed for better prevention and treatment of cancer. Cancer stem cells can be regulated at genomic, epigenomic and transcriptional levels. Mutations of driver genes are key to the formation of cancer stem cells. Epigenetic changes, such as DNA methylation and histone modification, also play important roles in cancer stem cell formation and drug resistance. In addition, transcription factors and their cofactors are critical for the maintenance and specification of cancer stem cells. In the past 20 years, genomics, epigenomics and transcriptomics studies have revolutionized our understanding of cancer stem cell, however, many questions remain largely elusive in both the mechanisms of cancer stem cell regulation and clinical application of targeting cancer stem cell.
The purpose of the Special Issue on “Genetic, Epigenetic and Transcriptional Regulation of Cancer Stem Cell” is to discuss new findings of cancer stem cell regulation mechanisms and targeting strategies. We are soliciting both original research articles and reviews that will update our readers on novel findings, current understandings as well as perspectives on the topic.
Prof. Dr. Haiquan Lu
Prof. Dr. Lulu Wang
Dr. Yongkang Yang
Guest Editors
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer stem cell
- genetics
- epigenetics
- gene mutation
- DNA methylation
- histone modification
- transcription factor
- transcription cofactor
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