Special Issue "Microflow (Bio)Catalysis"
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 552
Interests: microfluidics; biotransfomations; mathematical modeling; optimization
Interests: biocatalysis; microfluidics; enzyme kinetic; bioprocess engineering and development
Interests: microfluidics; biotransfomations; mathematical modeling; process automatisation
Interests: microreactors and microdevices; biodiesel; biogas; downstream processes; solid state fermentation; fermentation; enzymes; enzyme kinetics; mathematical modeling
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The development of the sustainable (bio)catalytic process includes research regarding (bio)catalyst selection and optimization, process conditions selection and optimization, as well as the reactor system selection and optimization. To achieve desirable productivity all three steps are equally important. Selected (bio)catalyst has to efficiently accept substrate, preferably under mild conditions (for example, ambient temperature, pressure, pH) and insure maximum product yield. Moreover, selected reactor system has to ensure simple process control.
Over the years, researchers showed numerous advantages of using microscale reactor systems for (bio)catalytic processes. Miniaturization of reaction space ensures time, space, and, moreover, costs reduction and ensures high volume productivities while operating in continuous mode. According to available literature, over 70% of fine chemical production processes would improve by continuous operation mode and for more than 50% of them microfluidic system would be the most suitable reactor system. The micro dimension of channels (dimeters under a millimeter in size) ensure numerous advantages over traditionally used macro reactor, for example: (i) use of small chemical and (bio)catalysts quantities, (ii) large surface to volume ratio (beneficial for extraction processes, as well as for the (bio)catalytic processes), (iii) efficient heat and mass transfer, (iv) predominantly laminar flow rate (Re<100), (v) possibility of performing single or multiphase reactions, etc. All listed advantages provide continuous substrate(s) and (bio)catalyst fed and continues products removal to prevents possible inhibitions. Moreover, to achieve sustainable (bio)catalytic process in a microfluidic device (bio)catalyst immobilization for their repeated usage was also introduced.
Furthermore, important aspect of research in field of microfluidic (bio)catalytic processes is also focused on application of simple or complex mathematical models. An efficient and reliable mathematical model includes hydrodynamics and kinetics of the process thus ensuring precise prediction of process productivity and allows the reduction of necessary experiments.
Based on everything previously stated, this Special Issue welcomes papers in area of:
- Microfluidic devices for (bio)catalytic processes;
- Flow description and control in microfluidic devices;
- Biotransformation’s with enzymes or whole cells;
- (Bio)catalyst immobilization in microfludic systems;
- Application of green solvents for (bio)catalysis in microfluidic systems;
- Process optimization;
- Multi-enzyme cascades and process integration;
- Kinetic studies and mathematical modeling;
- On-line monitoring of (bio)catalysis in microfluidic systems.
Dr. Ana Jurinjak Tušek
Dr. Anita Šalić
Dr. Davor Valinger
Prof. Dr. Bruno Zelić
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- (bio)catalysis in microfluidics
- (bio)catalyst immobilization
- process optimization
- mathematical modeling
- on-line monitoring of processes