Special Issue "Biocatalysis and Biotransformation of Extremozymes"
Deadline for manuscript submissions: 31 March 2021.
Interests: expression; purification and characterization of DNA- and carbohydrate-active enzymes from (hyper)thermophilic organisms; protein engineering for enzyme optimization employed as biotechnological tools
Interests: molecular biology and biochemistry of archaeal DNA replication; enzymes of plant cell wall hydrolysis
Interests: DNA metabolism and biochemical analysis of proteins and enzymes in particular related to DNA structure regulation and to the safeguard of genomic stability in (hyper)thermophiles
Interests: structure and function of cold-adapted proteins in marine organisms; evolutionary and physiological adaptations; oxidative/nitrosative stress; NO biology
“Normal is passé, extreme is chic”, as NASA’s Lynn J. Rothschild and Rocco L. Mancinelli said some years ago. The discovery of extreme environments and organisms which thrive in them had an impact on science similar to that on the refutation of the Ptolemaic vision. The awareness that the definition of life was very far from its "anthropocentric" connotation has in fact given a huge boost in various fields of knowledge, from basic research on the origin of life to astrobiology (life outside the Earth).
Undoubtedly, extremophilic microorganisms represent an impressive "treasure chest" of new enzymes, and their associated studies have led to the realization that biocatalysis goes beyond mild conditions, pushing the boundaries of pH, temperature, pressure, ionic environments and solvents, thought before to be destructive to biomolecules. Although yet to be fully realized, our understanding of the tenets underlying enzymatic function under extreme reaction conditions has led to the identification of some of the molecular mechanisms that play key roles in the success of extremozymes. Our expanded knowledge of the evolutionary trajectories of diverse enzymes across different environmental gradients therefore offers the opportunity to improve enzymes in terms of stability and activity, and/or the development of efficient, sustainable, and environmentally friendly industrial technologies.
This Special Issue is devoted to basic research on enzymes that function under harsh reaction conditions, for example in DNA transactions at high temperatures and/or radiations, or cellular metabolism under freezing water. We further welcome applied research that employs these biocatalysts in different “biotech” fields, including in the decomposition of hardly soluble and insoluble polymers for sustainable energy production and in food and detergent industries.
Reviews and original research papers from fundamental research to industrial application are welcome.
The main topics include but are not limited to:
- Enzyme evolution and adaptation;
- Catalysis at temperature extremes;
- Stabilization of mesophilic enzymes by protein engineering;
- DNA-associated extremozymes;
- Enzymes in polar environments;
- Extremophiles catalysts for sustainable bio-refineries;
- Novel and sustainable enzymes from marine extremophilic sources;- Biotechnology of extremozymes.
Dr. Giuseppe Perugino
Prof. Dr. Isaac Cann
Dr. Anna Valenti
Dr. Cinzia Verde
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Catalysts is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- biotechnological tools
- biotransformation in harsh conditions
- rational and irrational enzyme engineering
- enzyme evolution
- origin of life